Proteomic analysis of serum cytokine levels in response to highly active antiretroviral therapy (HAART)

被引：14
|
作者：
Relucio, KI
Beernink, HT
Chen, D
Israelski, DM
Kim, R
Holodniy, M
机构：
[1] Stanford Univ, Div Infect Dis & Geog Med, Stanford, CA USA
[2] Zyomyx Inc, Hayward, CA USA
[3] San Mateo Clin Trials & Res Unit, San Mateo, CA USA
[4] Vet Affairs Palo Alto Hlth Care Syst, AIDS Res Ctr, Palo Alto, CA USA
来源：
JOURNAL OF PROTEOME RESEARCH | 2005年 / 4卷 / 02期
关键词：
HIV; HAART; cytokines; antiretroviral therapy; proteomic chip; protein microarray; MIG; IP-10; CXCL9; CXCL10;
D O I：
10.1021/pr049930y
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A 30-cytokine protein microarray was used to screen for cytokine profile changes in HIV-infected patients in response to highly active antiretroviral therapy (HAART). Serum cytokines showing significant changes were confirmed by enzyme immunoassay. Monokine induced by gamma-interferon (MIG) and interferon-inducible protein-10 (IP-10) levels significantly decreased after 24 weeks of HAART. Protein microarrays are useful for initial screening of novel cytokine expression. Further studies are needed to elucidate the role of MIG and IP-10 in response to HAART.
引用
收藏
页码：227 / 231
页数：5
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