Proteomic analysis of serum cytokine levels in response to highly active antiretroviral therapy (HAART)

被引：14
|
作者：
Relucio, KI
Beernink, HT
Chen, D
Israelski, DM
Kim, R
Holodniy, M
机构：
[1] Stanford Univ, Div Infect Dis & Geog Med, Stanford, CA USA
[2] Zyomyx Inc, Hayward, CA USA
[3] San Mateo Clin Trials & Res Unit, San Mateo, CA USA
[4] Vet Affairs Palo Alto Hlth Care Syst, AIDS Res Ctr, Palo Alto, CA USA
来源：
JOURNAL OF PROTEOME RESEARCH | 2005年 / 4卷 / 02期
关键词：
HIV; HAART; cytokines; antiretroviral therapy; proteomic chip; protein microarray; MIG; IP-10; CXCL9; CXCL10;
D O I：
10.1021/pr049930y
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A 30-cytokine protein microarray was used to screen for cytokine profile changes in HIV-infected patients in response to highly active antiretroviral therapy (HAART). Serum cytokines showing significant changes were confirmed by enzyme immunoassay. Monokine induced by gamma-interferon (MIG) and interferon-inducible protein-10 (IP-10) levels significantly decreased after 24 weeks of HAART. Protein microarrays are useful for initial screening of novel cytokine expression. Further studies are needed to elucidate the role of MIG and IP-10 in response to HAART.
引用
收藏
页码：227 / 231
页数：5
相关论文
共 50 条
  • [31] Impact of Highly Active Antiretroviral Therapy (HAART) on Organs of HIV Infected Children in Abia State, Nigeria
    Ajulo, M. O.
    Omole, M. K.
    Moody, J. O.
    BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH, 2014, 4 (07): : 837 - 848
  • [32] The effects of highly active antiretroviral therapy on the serum levels of pro-inflammatory and anti-inflammatory cytokines in HIV infected subjects
    Faustina Nkechi Osuji
    Charles Chinedu Onyenekwe
    Joseph Ebere Ahaneku
    Nkiruka Rose Ukibe
    Journal of Biomedical Science, 25
  • [33] ASSESSMENT OF CYTOKINE VALUES IN SERUM BY RT-PCR IN HIV-1 INFECTED INDIVIDUALS WITH AND WITHOUT HIGHLY ACTIVE ANTI-RETROVIRAL THERAPY (HAART)
    Meira, D. A.
    Almeida, R. A. M. B.
    Barbosa, A. N.
    de Souza, L. R.
    Olivo, T. E. T.
    Henriques, R. M. S.
    Golim, M. A.
    Araujo Jr, J. P.
    Nagoshi, L. R.
    Orikaza, C. M.
    Calvi, S. A.
    JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES, 2008, 14 (04): : 685 - 702
  • [34] Significant decrease of the enhancement/neutralization index in HIV patients during highly active antiretroviral therapy (HAART)
    Bánhegyi, D
    Bácsi, A
    Tóth, FD
    Prohászka, Z
    Horváth, A
    Beck, Z
    Kónya, J
    Füst, G
    IMMUNOLOGY LETTERS, 2003, 89 (01) : 25 - 30
  • [35] The effects of highly active antiretroviral therapy on the serum levels of pro-inflammatory and anti-inflammatory cytokines in HIV infected subjects
    Osuji, Faustina Nkechi
    Onyenekwe, Charles Chinedu
    Ahaneku, Joseph Ebere
    Ukibe, Nkiruka Rose
    JOURNAL OF BIOMEDICAL SCIENCE, 2018, 25
  • [36] Editorial - Role of Highly Active Antiretroviral Therapy (HAART) for the COVID-19 treatment
    Nastri, B. M.
    Zannella, C.
    Folliero, V.
    Rinaldi, L.
    Restivo, L.
    Stelitano, D.
    Sperlongano, R.
    Adinolfi, L. E.
    Franci, G.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2020, 24 (22) : 11982 - 11984
  • [37] A New Start with HAART: Evaluating Breast Reconstruction in the Era of Highly Active Antiretroviral Therapy
    Amakiri, Uchechukwu O.
    Shah, Jennifer K.
    Akhter, Maheen F.
    Fung, Ethan
    Sheckter, Clifford C.
    Nazerali, Rahim S.
    PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN, 2024, 12 (08) : e6040
  • [38] Selected Micronutrient Levels and Response to Highly Active Antiretroviral Therapy (HAART) Among HIV/AIDS Patients Attending a Teaching Hospital in Addis Ababa, Ethiopia
    Amare Eshetu
    Aster Tsegaye
    Beyene Petros
    Biological Trace Element Research, 2014, 162 : 106 - 112
  • [39] HIV-associated bacteremia: How it has changed in the highly active antiretroviral therapy (HAART) era
    Tumbarello, M
    Tacconelli, E
    Donati, KD
    Citton, R
    Leone, F
    Spanu, T
    Cauda, R
    JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2000, 23 (02) : 145 - 151
  • [40] Selected Micronutrient Levels and Response to Highly Active Antiretroviral Therapy (HAART) Among HIV/AIDS Patients Attending a Teaching Hospital in Addis Ababa, Ethiopia
    Eshetu, Amare
    Tsegaye, Aster
    Petros, Beyene
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2014, 162 (1-3) : 106 - 112
12345