Regionally specific effects of BDNF on oligodendrocytes

被引：91

作者：

Du, YZ ^{[1
]}

Fischer, TZ ^{[1
]}

Lee, LN ^{[1
]}

Lercher, LD ^{[1
]}

Dreyfus, CF ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurosci & Cell Biol, Piscataway, NJ 08854 USA

来源：

DEVELOPMENTAL NEUROSCIENCE | 2003年 / 25卷 / 2-4期

关键词：

glial heterogeneity; neurotrophins; glial development;

D O I：

10.1159/000072261

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To define the effects of neurotrophins on oligodendrocytes, we monitored NGF, BDNF and NT-3 actions on basal forebrain (BF) and cortical populations. NGF, BDNF and NT-3 applied to BF oligodendrocytes elicited increases in expression of myelin basic protein (MBP) and enhanced the numbers of MBP+ cells, without affecting total cell numbers. In the cortex, however, while NGF and NT-3 influenced MBP expression, BDNF was without effect. To explore this apparent regional difference in BDNF action, we compared expression of the neurotrophin receptors trkA, trkB and trkC. While BF cells expressed all three trks, cortical cells did not express the full-length BDNF receptor, trkB. Interestingly, in no case was any receptor expressed by all oligodendrocytes, indicating that oligodendrocytes may be heterogeneous within a brain region. The data suggest that BF oligodendrocytes are influenced by BDNF to express MBP and are distinct in this ability from cortical cells. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：116 / 126

页数：11

共 48 条

[41] Cerebellar pathology in BDNF -/- mice: the classic view of neurotrophins is changing [J].