A polymerization-depolymerization model that accurately generates the self-sustained oscillatory system involved in bacterial division site placement

被引：56
作者：
Drew, DA
Osborn, MJ
Rothfield, LI [1 ]
机构：
[1] Univ Connecticut, Ctr Hlth, Dept Mol Microbial & Struct Biol, Farmington, CT 06032 USA
[2] Rensselaer Polytech Inst, Dept Math Sci, Troy, NY 12180 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2005年 / 102卷 / 17期
关键词：
Min; cell division; cytoskeleton;
D O I：
10.1073/pnas.0502037102
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Determination of the proper site ford division in Escherichia coli and other bacteria involves a unique spatial oscillatory system in which membrane-associated structures composed of the MinC, MinD and MinE proteins oscillate rapidly between the two cell poles. In vitro evidence indicates that this involves ordered cycles of assembly and disassembly of MinD polymers. We propose a mathematical model to explain this behavior. Unlike previous attempts, the present approach is based on the expected behavior of polymerization-depolymerization systems and incorporates current knowledge of the biochemical properties of MinD and MinE. Simulations based on the model reproduce all of the known topological and temporal characteristics of the in vivo oscillatory system.
引用
收藏
页码：6114 / 6118
页数：5
相关论文
共 23 条
[1]   Targeting of the chemotaxis methylesterase/deamidase CheB to the polar receptor-kinase cluster in an Escherichia coli cell [J].
Banno, S ;
Shiomi, D ;
Homma, M ;
Kawagishi, I .
MOLECULAR MICROBIOLOGY, 2004, 53 (04) :1051-1063
[2]   Protein mobility in the cytoplasm of Escherichia coli [J].
Elowitz, MB ;
Surette, MG ;
Wolf, PE ;
Stock, JB ;
Leibler, S .
JOURNAL OF BACTERIOLOGY, 1999, 181 (01) :197-203
[3]   The MinE ring required for proper placement of the division site is a mobile structure that changes its cellular location during the Escherichia coli division cycle [J].
Fu, XL ;
Shih, YL ;
Zhang, Y ;
Rothfield, LI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (03) :980-985
[4]   Dynamic localization cycle of the cell division regulator MinE in Escherichia coli [J].
Hale, CA ;
Meinhardt, H ;
de Boer, PAJ .
EMBO JOURNAL, 2001, 20 (07) :1563-1572
[5]   Dynamic compartmentalization of bacteria: Accurate division in E-coli - art. no. 278102 [J].
Howard, M ;
Rutenberg, AD ;
de Vet, S .
PHYSICAL REVIEW LETTERS, 2001, 87 (27) :278102-278102
[6]   Topological regulation of cell division in Escherichia coli involves rapid pole to pole oscillation of the division inhibitor MinC under the control of MinD and MinE [J].
Hu, ZL ;
Lutkenhaus, J .
MOLECULAR MICROBIOLOGY, 1999, 34 (01) :82-90
[7]   Topological regulation of cell division in E-coli: Spatiotemporal oscillation of MinD requires stimulation of its ATPase by MinE and phospholipid [J].
Hu, ZL ;
Lutkenhaus, J .
MOLECULAR CELL, 2001, 7 (06) :1337-1343
[8]   Dynamic structures in Escherichia coli: Spontaneous formation of MinE rings and MinD polar zones [J].
Huang, KC ;
Meir, Y ;
Wingreen, NS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (22) :12724-12728
[9]   Evidence for polar positional information independent of cell division and nucleoid occlusion [J].
Janakiraman, A ;
Goldberg, MB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (03) :835-840
[10]   A dynamic model for determining the middle of Escherichia coli [J].
Kruse, K .
BIOPHYSICAL JOURNAL, 2002, 82 (02) :618-627
123