Reaction mechanisms of mononuclear non-heme iron oxygenases

被引：512

作者：

Abu-Omar, MM ^{[1
]}

Loaiza, A ^{[1
]}

Hontzeas, N ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

CHEMICAL REVIEWS | 2005年 / 105卷 / 06期

关键词：

D O I：

10.1021/cr040653o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A large number of non-heme iron enzymes are known to catalyze a wide range of reactions with molecular oxygen. This review presents and analyzes results obtained in the past six years from primary sequences, structure-function relationships, and chemical kinetics and mechanisms, dealing with mononuclear non-heme iron inter- and intramolecular dioxygenases. Focus is on the pterin-dependent aromatic amino acid hydroxylases. Comments are added wherever appropriate to tie in and emphasize mechanistic information that is pertinent to the enzyme's function and selectivity.

引用

收藏

页码：2227 / 2252

页数：26

相关论文

共 227 条

[1]

ABELES FB, 1992, ETHYELENE PLANT BIOL

[2] 14-3-3 and its possible role in co-ordinating multiple signalling pathways [J].

Aitken, A .

TRENDS IN CELL BIOLOGY, 1996, 6 (09) :341-347

[3] A kinetic and conformational study on the interaction of tetrahydropteridines with tyrosine hydroxylase [J].

Almås, B ;

Toska, K ;

Teigen, K ;

Groehn, V ;

Pfleiderer, W ;

Martínez, A ;

Flatmark, T ;

Haavik, J .

BIOCHEMISTRY, 2000, 39 (45) :13676-13686

[4] 2.0 Å resolution crystal structures of the ternary complexes of human phenylalanine hydroxylase catalytic domain with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine or L-norleucine:: Substrate specificity and molecular motions related to substrate binding [J].

Andersen, OA ;

Stokka, AJ ;

Flatmark, T ;

Hough, E .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 333 (04) :747-757

[5] Crystal structure of the ternary complex of the catalytic domain of human phenylalanine hydroxylase with tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its implications for the mechanism of catalysis and substrate activation [J].

Andersen, OA ;

Flatmark, T ;

Hough, E .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 320 (05) :1095-1108

[6]

ANDERSSON KK, 1988, J BIOL CHEM, V263, P18621

[7]

[Anonymous], 1988, OXYGEN COMPLEXES OXY

[8] INHIBITION OF THE CONVERSION OF 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID TO ETHYLENE BY STRUCTURAL ANALOGS, INHIBITORS OF ELECTRON-TRANSFER, UNCOUPLERS OF OXIDATIVE-PHOSPHORYLATION, AND FREE-RADICAL SCAVENGERS [J].

APELBAUM, A ;

WANG, SY ;

BURGOON, AC ;

BAKER, JE ;

LIEBERMAN, M .

PLANT PHYSIOLOGY, 1981, 67 (01) :74-79

[9] PHOSPHORYLATION OF PURIFIED RAT STRIATAL TYROSINE-HYDROXYLASE BY CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE-II - EFFECT OF AN ACTIVATOR PROTEIN [J].

ATKINSON, J ;

RICHTAND, N ;

SCHWORER, C ;

KUCZENSKI, R ;

SODERLING, T .

JOURNAL OF NEUROCHEMISTRY, 1987, 49 (04) :1241-1249

[10] DISCRETE STEPS IN DIOXYGEN ACTIVATION - THE CYTOCHROME-OXIDASE O-2 REACTION [J].

BABCOCK, GT ;

VAROTSIS, C .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1993, 25 (02) :71-80

← 1 2 3 4 5 6 7 8 9 10 →