microRNAs: Small molecules with a large impact on colorectal cancer

被引：11

作者：

Moazzendizaji, Sahand ^{[1
]}

Sevbitov, Andrey ^{[2
]}

Ezzatifar, Fatemeh ^{[3
,4
]}

Jalili, Hamid Reza ^{[1
]}

Aalii, Morteza ^{[5
]}

Hemmatzadeh, Maryam ^{[6
]}

Aslani, Saeed ^{[7
]}

Navashenaq, Jamshid Gholizadeh ^{[8
]}

Safari, Roghaiyeh ^{[9
,10
]}

Hosseinzadeh, Ramin ^{[7
]}

Rahmany, Mohammad Reza ^{[1
]}

Mohammadi, Hamed ^{[11
,12
]}

机构：

[1] Kurdistan Univ Med Sci, Fac Med, Dept Immunol, Sanandaj, Iran

[2] Sechenov Univ, IM Sechenov First Moscow State Med Univ, Dept Propaedeut Dent Dis, Moscow, Russia

[3] Mazandaran Univ Med Sci, Fac Med, Mol & Cell Biol Res Ctr, Sari, Iran

[4] Mazandaran Univ Med Sci, Sch Med, Dept Immunol, Sari, Iran

[5] Rafsanjan Univ Med Sci, Sch Med, Dept Immunol, Rafsanjan, Iran

[6] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[7] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[8] Bam Univ Med Sci, Noncommunicable Dis Res Ctr, Bam, Iran

[9] Univ Liege, Mol & Cellular Epigenet GIGA, Sart Tilman Par Liege, Belgium

[10] Univ Liege, Gembloux Agrobio Tech, Mol & Cellular Biol TERRA 13, Gembloux, Belgium

[11] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran

[12] Alborz Univ Med Sci, Sch Med, Dept Immunol, Karaj, Iran

来源：

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY | 2022年 / 69卷 / 05期

关键词：

colorectal cancer; microRNAs; signaling pathways; BINDING SITE POLYMORPHISM; COLON-CANCER; PROGNOSTIC BIOMARKER; CELL-PROLIFERATION; TUMOR-SUPPRESSOR; POOR-PROGNOSIS; STAGE-II; CATENIN PATHWAY; DOWN-REGULATION; RECTAL-CANCER;

D O I：

10.1002/bab.2255

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal cancer (CRC) accounts for one of the main cancer-related mortality and morbidity worldwide. The molecular mechanisms of CRC development have been broadly investigated and, over the last decade, it has become evident that aberrant transcription of microRNAs (miRNAs), a class of small, noncoding RNA molecules, has a significant role in the inception and promotion of CRC. In the involved tissues of CRC, the transcription profile of miRNAs is modulated, and their expression templates are related with prognosis, diagnosis, and treatment outcomes. Here, in the current review, we attempted to discuss the latest information regarding the aberrantly expressed miRNAs in CRC and the advantages of utilizing miRNAs as biomarkers for early diagnosis and prognosis of CRC as well as potential therapeutic application. The effect of miRNAs involved in various signaling pathways, primarily p53, EGFR, Wnt, and TGF-beta pathways, was clarified.

引用

页码：1893 / 1908

页数：16

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