Tranexamic Acid to Reduce Blood Loss After Bilateral Total Knee Arthroplasty A Prospective, Randomized Double Blind Study

被引:101
作者
MacGillivray, Robin G. [1 ]
Tarabichi, Samih B. [2 ]
Hawari, Marwan F. [2 ]
Raoof, Nayzak T. [1 ]
机构
[1] Amer Hosp Dubai, Dept Anesthesia, Dubai, U Arab Emirates
[2] Amer Hosp Dubai, Dept Orthoped, Dubai, U Arab Emirates
关键词
bilateral total knee arthroplasty; blood loss; transfusion; tranexamic acid; REPLACEMENT; TRIAL; TRANSFUSIONS; METAANALYSIS; SUBVASTUS;
D O I
10.1016/j.arth.2009.11.013
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
The effects of 2-dosage regimens of tranexamic acid (10 mg/kg and 15 mg/kg) on blood loss and transfusion requirement were compared to saline placebo in 60 patients undergoing concurrent bilateral total knee arthroplasty, with additional reinfusion autotransfusion from intraarticular drains. Mean blood loss was 462 mL in 15 mL/kg group, 678 mL in 10 mg/kg group, and 918 mL in controls (P < .01 vs 15 mg/kg). Blood available for autotransfusion was greatest in controls and least in 15 mg/kg group. Combined autologous and allogenic transfusion volumes were similar in the treatment groups and significantly less than controls (P < .01). With use of an autologous reinfusion strategy, the lower dose is sufficient to lead to a lesser allogenic transfusion requirement.
引用
收藏
页码:24 / 28
页数:5
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