Oriented conjugates of single-domain antibodies and fluorescent quantum dots for highly sensitive detection of tumor-associated biomarkers in cells and tissues

被引：6
作者：
Bilan, Regina [1 ]
Brazhnik, Kristina [1 ]
Chames, Patrick [2 ,3 ,4 ]
Baty, Daniel [2 ,3 ,4 ]
Nabiev, Igor [1 ,5 ]
Sukhanova, Alyona [1 ,5 ]
机构：
[1] Natl Res Nucl Univ MEPhI, Moscow Engn Phys Inst, 31 Kashirskoe Shosse, Moscow 115409, Russia
[2] INSERM, U1068, F-13009 Marseille, France
[3] CNRS, CRCM, UMR7258, Inst Paoli Calmettes, F-13009 Marseille, France
[4] Univ Aix Marseille, F-13009 Marseille, France
[5] Univ Reims, LRN EA4682, Lab Rech Nanosci, F-51100 Reims, France
来源：
4TH INTERNATIONAL CONFERENCE OF PHOTONICS AND INFORMATION OPTICS, PHIO 2015 | 2015年 / 73卷
关键词：
quantum dots (QDs); cancer markers; single-domain antibodies (sdAbs); bioconjugates; CANCER-CELLS; IN-VIVO; DELIVERY;
D O I：
10.1016/j.phpro.2015.09.162
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Our recent results in the field of engineering and application of highly oriented conjugates of single-domain antibodies and fluorescent quantum dots are summarized. These novel conjugates proved to be excellent nanoprobes for immunolabeling of tumor-associated biomarkers on cells and tissue specimens detectable by means of flow cytometry or one- or two-photon confocal microscopy. The results are discussed in terms of the most promising future applications of these conjugates and further developments in this field. (C) 2015 The Authors. Published by Elsevier B.V.
引用
收藏
页码：228 / 234
页数：7
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