Association between antifol resistance in vitro and DHFR gene point mutation in Plasmodium falciparum isolates

被引：29

作者：

dePecoulas, PE ^{[1
]}

Basco, LK ^{[1
]}

LeBras, J ^{[1
]}

Mazabraud, A ^{[1
]}

机构：

[1] HOP BICHAT CLAUDE BERNARD,PARASITOL LAB,F-75877 PARIS,FRANCE

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1996年 / 90卷 / 02期

关键词：

malaria; Plasmodium falciparum; antifol resistance; DHFR gene mutation;

D O I：

10.1016/S0035-9203(96)90130-3

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

[No abstract available]

引用

页码：181 / 182

页数：2

共 6 条

[1] POINT MUTATIONS IN THE DIHYDROFOLATE-REDUCTASE THYMIDYLATE SYNTHASE GENE AND PYRIMETHAMINE AND CYCLOGUANIL RESISTANCE IN PLASMODIUM-FALCIPARUM [J].

BASCO, LK ;

DEPECOULAS, PE ;

WILSON, CM ;

LEBRAS, J ;

MAZABRAUD, A .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1995, 69 (01) :135-138

[2] IN-VITRO ACTIVITY OF PYRIMETHAMINE, CYCLOGUANIL, AND OTHER ANTIMALARIAL-DRUGS AGAINST AFRICAN ISOLATES AND CLONES OF PLASMODIUM-FALCIPARUM [J].

BASCO, LK ;

RAMILIARISOA, O ;

LEBRAS, J .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1994, 50 (02) :193-199

[3] PLASMODIUM-FALCIPARUM - DETECTION OF ANTIFOLATE RESISTANCE BY MUTATION-SPECIFIC RESTRICTION ENZYME DIGESTION [J].

DEPECOULAS, PE ;

BASCO, LK ;

ABDALLAH, B ;

DJE, MK ;

LEBRAS, J ;

MAZABRAUD, A .

EXPERIMENTAL PARASITOLOGY, 1995, 80 (03) :483-487

[4] AMINO-ACIDS IN THE DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE GENE OF PLASMODIUM-FALCIPARUM INVOLVED IN CYCLOGUANIL RESISTANCE DIFFER FROM THOSE INVOLVED IN PYRIMETHAMINE RESISTANCE [J].

FOOTE, SJ ;

GALATIS, D ;

COWMAN, AF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3014-3017

[5] PREVALENCE OF THE DIHYDROFOLATE-REDUCTASE ASN-108 MUTATION AS THE BASIS FOR PYRIMETHAMINE-RESISTANT FALCIPARUM-MALARIA IN THE BRAZILIAN AMAZON [J].

PETERSON, DS ;

DISANTI, SM ;

POVOA, M ;

CALVOSA, VS ;

DOROSARIO, VE ;

WELLEMS, TE .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1991, 45 (04) :492-497

[6] MOLECULAR-BASIS OF DIFFERENTIAL RESISTANCE TO CYCLOGUANIL AND PYRIMETHAMINE IN PLASMODIUM-FALCIPARUM MALARIA [J].

PETERSON, DS ;

MILHOUS, WK ;

WELLEMS, TE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3018-3022

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