The NETest The Clinical Utility of Multigene Blood Analysis - in the Diagnosis and Management of Neuroendocrine Tumors

被引：105

作者：

Modlin, Irvin M. ^{[1
]}

Kidd, Mark ^{[2
]}

Malczewska, Anna ^{[3
]}

Drozdov, Ignat ^{[2
]}

Bodei, Lisa ^{[4
]}

Matar, Sourer ^{[2
]}

Chung, Kyung-Min ^{[2
]}

机构：

[1] Yale Univ, Sch Med, Gastroenterol & Endoscop Surg, 310 Cedar St, New Haven, CT 06520 USA

[2] Wren Labs, 35 NE Ind Rd, Branford, CT 06405 USA

[3] Med Univ Silesia, Dept Endocrinol & Neuroendocrine Tumors, Ul Ceglana 35, PL-40514 Katowice, Poland

[4] Mem Sloan Kettering Canc Ctr, 1275 York Ave,Box 77, New York, NY 10065 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2018年 / 47卷 / 03期

关键词：

NETest; Multigene blood analysis; Neuroendocrine tumors; Peptide receptor radionuclide therapy; Bronchopulomary carcinoid; Transcript; Progression; PCR; Blood; Biomarker; POLYMERASE CHAIN-REACTION; CHROMOGRANIN-A; TRANSCRIPT ANALYSIS; HEPATIC METASTASES; PROGNOSTIC-FACTORS; LIQUID BIOPSIES; LUNG-CANCER; HALLMARKS; EXPRESSION; SURVIVAL;

D O I：

10.1016/j.ecl.2018.05.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The neuroendocrine neoplasms test (NETest) is a multianalyte liquid biopsy that measures neuroendocrine tumor gene expression in blood. This unique signature precisely defines the biological activity of an individual tumor in real time. The assay meets the 3 critical requirements of an optimal biomarker: diagnostic accuracy, prognostic value, and predictive therapeutic assessment. NETest performance metrics are sensitivity and specificity and in head-to-head comparison are 4-fold to 10-fold more accurate than chromogranin A. NETest accurately identifies completeness of surgery and response to somatostatin analogs. Clinical registry data demonstrate significant clinical utility in watch/wait programs.

引用

页码：485 / +

页数：22

共 81 条

[41] The role of liquid biopsies to manage and predict PRRT for NETs [J].

Kidd, Mark ;

Modlin, Irvin M. .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2017, 14 (06) :331-332

[42] Towards a new classification of gastroenteropancreatic neuroendocrine neoplasms [J].

Kidd, Mark ;

Modlin, Irvin ;

Oberg, Kjell .

NATURE REVIEWS CLINICAL ONCOLOGY, 2016, 13 (11) :691-705

[43] Decoding the Molecular and Mutational Ambiguities of Gastroenteropancreatic Neuroendocrine Neoplasm Pathobiology [J].

Kidd, Mark ;

Modlin, Irvin M. ;

Bodei, Lisa ;

Drozdov, Ignat .

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2015, 1 (02) :131-153

[44] Blood and tissue neuroendocrine tumor gene cluster analysis correlate, define hallmarks and predict disease status [J].

Kidd, Mark ;

Drozdov, Ignat ;

Modlin, Irvin .

[45] Gene network-based analysis identifies two potential subtypes of small intestinal neuroendocrine tumors [J].

Kidd, Mark ;

Modlin, Irvin M. ;

Drozdov, Ignat .

BMC GENOMICS, 2014, 15

[46] Machine learning for medical diagnosis: history, state of the art and perspective [J].

Kononenko, I .

ARTIFICIAL INTELLIGENCE IN MEDICINE, 2001, 23 (01) :89-109

[47] Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Focused Update [J].

Krop, Ian ;

Ismaila, Nofisat ;

Andre, Fabrice ;

Bast, Robert C. ;

Barlow, William ;

Collyar, Deborah E. ;

Hammond, M. Elizabeth ;

Kuderer, Nicole M. ;

Liu, Minetta C. ;

Mennel, Robert G. ;

Van Poznak, Catherine ;

Wolff, Antonio C. ;

Stearns, Vered .

JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (24) :2838-+

[48] The Clinical Relevance of Chromogranin A as a Biomarker for Gastroenteropancreatic Neuroendocrine Tumors [J].

Lawrence, Ben ;

Gustafsson, Bjorn I. ;

Kidd, Mark ;

Pavel, Marianne ;

Svejda, Bernhard ;

Modlin, Irvin M. .

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2011, 40 (01) :111-+

[49] A Comprehensive Assessment of the Role of miRNAs as Biomarkers in Gastroenteropancreatic Neuroendocrine Tumors [J].

Malczewska, Anna ;

Kidd, Mark ;

Matar, Somer ;

Kos-Kudla, Beata ;

Modlin, Irvin M. .

NEUROENDOCRINOLOGY, 2018, 107 (01) :73-90

[50] Consensus Report of a Joint NCI Thoracic Malignancies Steering Committee: FDA Workshop on Strategies for Integrating Biomarkers into Clinical Development of New Therapies for Lung Cancer Leading to the Inception of "Master Protocols" in Lung Cancer [J].

Malik, Shakun M. ;

Pazdur, Richard ;

Abrams, Jeffrey S. ;

Socinski, Mark A. ;

Sause, William T. ;

Harpole, David H., Jr. ;

Welch, John J. ;

Korn, Edward L. ;

Ullmann, Claudio Dansky ;

Hirsch, Fred R. .

JOURNAL OF THORACIC ONCOLOGY, 2014, 9 (10) :1443-1448

← 1 2 3 4 5 6 7 8 9 →