Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development

被引：12

作者：

Chang, Yi-Cheng ^{[1
,2
]}

Manent, Jan ^{[1
,2
]}

Schroeder, Jan ^{[2
,3
,4
]}

Wong, Siew Fen Lisa ^{[1
,2
]}

Hauswirth, Gabriel M. ^{[1
,2
]}

Shylo, Natalia A. ^{[5
]}

Moore, Emma L. ^{[5
]}

Achilleos, Annita ^{[5
,6
]}

Garside, Victoria ^{[1
,2
]}

Polo, Jose M. ^{[2
,3
,4
]}

Trainor, Paul ^{[5
,7
]}

McGlinn, Edwina ^{[1
,2
]}

机构：

[1] Monash Univ, EMBL Australia, Clayton, Vic 3800, Australia

[2] Monash Univ, Australian Regenerat Med Inst, Clayton, Vic 3800, Australia

[3] Monash Univ, Dept Anat & Dev Biol, Clayton, Vic, Australia

[4] Monash Biomed Discovery Inst, Dev & Stem Cells Program, Clayton, Vic, Australia

[5] Stowers Inst Med Res, Kansas City, MO USA

[6] Univ Nicosia, Nicosia, Cyprus

[7] Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66103 USA

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

基金：

澳大利亚研究理事会;

关键词：

CELL NUCLEAR FACTOR; LUNATIC-FRINGE; RECEPTOR GCNF; AXIAL PROGENITORS; MOUSE EMBRYOS; TAIL BUD; GENE; SEGMENTATION; EVOLUTION; MESODERM;

D O I：

10.1038/s41467-022-35303-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The vertebrate main-body axis is laid down during embryonic stages in an anterior-to-posterior (head-to-tail) direction, driven and supplied by posteriorly located progenitors. Whilst posterior expansion and segmentation appears broadly uniform along the axis, there is developmental and evolutionary support for at least two discrete modules controlling processes within different axial regions: a trunk and a tail module. Here, we identify Nuclear receptor subfamily 6 group A member 1 (Nr6a1) as a master regulator of trunk development in the mouse. Specifically, Nr6a1 was found to control vertebral number and segmentation of the trunk region, autonomously from other axial regions. Moreover, Nr6a1 was essential for the timely progression of Hox signatures, and neural versus mesodermal cell fate choice, within axial progenitors. Collectively, Nr6a1 has an axially-restricted role in all major cellular and tissue-level events required for vertebral column formation, supporting the view that changes in Nr6a1 levels may underlie evolutionary changes in axial formulae.

引用

页数：19

共 106 条

[1] Predicting effective microRNA target sites in mammalian mRNAs [J].