Comprehensive Review on Versatile Pharmacology of Quinoxaline Derivative

被引：12

作者：

V. Bala Aakash ^{[1
]}

Ramalakshmi, N. ^{[1
]}

Bhuvaneswari, S. ^{[1
]}

Sankari, E. ^{[1
]}

Arunkumar, S. ^{[2
]}

机构：

[1] CL Baid Metha Coll Pharm, Chennai 600097, Tamil Nadu, India

[2] Sathyabama Inst Sci & Technol, Sch Pharm, Chennai 600119, Tamil Nadu, India

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2022年 / 48卷 / 04期

关键词：

quinoxaline; biological activity; IC50; value; anti-microbial; anti-cancer; anti-malarial; BIOLOGICAL EVALUATION; 1,4-DI-N-OXIDE DERIVATIVES; ANTICANCER; DESIGN; BRIMONIDINE; INHIBITORS; DISCOVERY; ANTIOXIDANT; GLAUCOMA;

D O I：

10.1134/S1068162022040069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quinoxaline is a nitrogen-containing heterocyclic compound having many pharmaceutical and industrial purposes. It can be synthesized by adopting green chemistry principles. The quinoxaline containing drugs such as Olaquindox, Echinomycin, Atinoleutin, Levomycin, and Carbadox are currently used as an antibiotic in the market. The objective of this review is to enumerate the various multifunctional property of the quinoxaline moiety. This present review contains the newer quinoxaline derivatives against many targets, receptors, or microorganisms. This work comprises the study on quinoxaline as a core unit from the year 2002 to 2020. All the collected literature has been combined and highlighted for the effective use of that particular derivative. Various potent quinoxaline compounds have been analyzed in the literature. About 50 papers have been reviewed for the novel quinoxaline compounds, the potent derivatives have been reported, and structures were given. The critical role of the quinoxaline on the various heterocyclic moieties has been given more attention in this review. This review paves the way as a source of references for the further development of drug discovery in the wide spectrum of its biological importance.

引用

页码：657 / 677

页数：21

共 80 条

[1] Molecular modeling studies and synthesis of novel quinoxaline derivatives with potential anticancer activity as inhibitors of c-Met kinase [J].

Abbas, Hebat-Allah S. ;

Al-Marhabi, Aisha R. ;

Eissa, Sally I. ;

Ammar, Yousry A. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (20) :6560-6572

[2] Synthesis, characterization and antiamoebic activity of 1-(thiazolo[4,5-b]quinoxaline-2-yl)-3-phenyl-2-pyrazoline derivatives [J].

Abid, M ;

Azam, A .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (10) :2812-2816

[3] Discovery of novel [1,2,4]triazolo[4,3-a]quinoxaline aminophenyl derivatives as BET inhibitors for cancer treatment [J].

Ali, Imran ;

Lee, Jooyun ;

Go, Areum ;

Choi, Gildon ;

Lee, Kwangho .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (20) :4606-4613

[4] Design, synthesis, antimicrobial activity and molecular docking studies of some novel di-substituted sulfonylquinoxaline derivatives [J].

Ammar, Yousry A. ;

Farag, Awatef A. ;

Ali, Abeer M. ;

Ragab, Ahmed ;

Askar, Ahmed A. ;

Elsisi, Doaa M. ;

Belal, Amany .

BIOORGANIC CHEMISTRY, 2020, 104

[5]

[Anonymous], 1884, BER DTSCH CHEM GES, DOI DOI 10.1002/CBER.188401701157

[6] New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities [J].

Barea, Carlos ;

Pabon, Adriana ;

Perez-Silanes, Silvia ;

Galiano, Silvia ;

Gonzalez, German ;

Monge, Antonio ;

Deharo, Eric ;

Aldana, Ignacio .

MOLECULES, 2013, 18 (04) :4718-4727

[7] Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives [J].

Barea, Carlos ;

Pabon, Adriana ;

Galiano, Silvia ;

Perez-Silanes, Silvia ;

Gonzalez, German ;

Deyssard, Chloe ;

Monge, Antonio ;

Deharo, Eric ;

Aldana, Ignacio .

MOLECULES, 2012, 17 (08) :9451-9461

[8]

Brown D. J., 1950, Chemistry of Heterocyclic Compounds

[9] Synthesis and Biological Evaluation of New Quinoxaline Derivatives as Antioxidant and Anti-Inflammatory Agents [J].

Burguete, Asuncion ;

Pontiki, Eleni ;

Hadjipavlou-Litina, Dimitra ;

Ancizu, Saioa ;

Villar, Raquel ;

Solano, Beatriz ;

Moreno, Elsa ;

Torres, Enrique ;

Perez, Silvia ;

Aldana, Ignacio ;

Monge, Antonio .

CHEMICAL BIOLOGY & DRUG DESIGN, 2011, 77 (04) :255-267

[10] LEVOMYCIN .1. ISOLATION AND CHEMICAL STUDIES [J].

CARTER, HE ;

SCHAFFNER, CP ;

GOTTLIEB, D .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1954, 53 (01) :282-293

← 1 2 3 4 5 6 7 8 →