Postmarketing surveillance of corneal edema, Fuchs dystrophy, and amantadine use in the veterans health administration

被引:20
作者
French, Dustin D.
Margo, Curtis E.
机构
[1] VISN8 Patient Safety Ctr Inquiry, Tampa, FL 33613 USA
[2] James A Haley Hosp, Sect Ophthalmol, Tampa, FL USA
关键词
amantadine; corneal edema; Fuchs dystrophy; drug safety;
D O I
10.1097/ICO.0b013e3181450d4c
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To determine the proportion of patients who were dispensed amantadine and diagnosed with corneal edema or Fuchs dystrophy within specified time frames. Methods: Postmarketing surveillance study. The national Veterans Health Administration pharmacy and clinical databases were used to identify a cohort of veterans without a prior history of corneal edema, Fuchs dystrophy, or a prescription for amantadine. During fiscal years 2005-2006, 2 databases were used to identify patients with new diagnoses of corneal disease and new prescriptions for amantadine. Patients from each were cross-referenced. The outcome measure was concurrent diagnosis of corneal edema or Fuchs dystrophy and new prescription for amantadine within specified intervals. Results: Thirty-six (0.27%) patients among the 13,137 who were dispensed amantadine were diagnosed with corneal edema or Fuchs dystrophy within the 2-year study period. The relative risk of corneal edema for a person prescribed amantadine was 1.7 (95% confidence interval: 1.1-2.8). In 12 (0.09%) patients, the corneal diagnoses were recorded within a month of being prescribed amantadine. Conclusions: Retrospective examination of a large national medical database revealed that amantadine was temporally associated with a small proportion of patients diagnosed with corneal edema or Fuchs dystrophy. Although additional studies are needed to confirm the risk of corneal edema with amantadine, the development of corneal edema in persons prescribed amantadine warrants clinical attention. In such a situation, physicians may consider stopping amantadine to see if the edema subsides.
引用
收藏
页码:1087 / 1089
页数:3
相关论文
共 11 条
  • [1] AMANTADINE CAUSED CORNEAL EDEMA
    BLANCHARD, DL
    [J]. CORNEA, 1990, 9 (02) : 181 - 181
  • [2] Brunton LL., 2018, GOODMAN GILMANS PHAR
  • [3] Fraunfelder F., 2001, DRUG INDUCED OCULAR
  • [4] Scientific challenges in postmarketing surveillance of ocular adverse drug reactions
    Fraunfelder, Frederick W.
    Fraunfelder, Frederick T.
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 2007, 143 (01) : 145 - 149
  • [5] Outpatient medications and hip fractures in the US - A national veterans study
    French, DD
    Campbell, R
    Spehar, A
    Cunningham, F
    Foulis, P
    [J]. DRUGS & AGING, 2005, 22 (10) : 877 - 885
  • [6] FRENCH DD, 2006, J PATIENT SAF, V2, P78
  • [7] Galor A, 2007, EYE NET, P41
  • [8] Antiviral management of seasonal and pandemic influenza
    Hayden, Frederick G.
    Pavia, Andrew T.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2006, 194 : S119 - S126
  • [9] Reversible amantadine-induced corneal edema in an adolescent
    Hughes, B
    Feiz, V
    Flynn, SB
    Brodsky, MC
    [J]. CORNEA, 2004, 23 (08) : 823 - 824
  • [10] Ischemic optic neuropathy in male veterans prescribed phosphodiesterase-5 inhibitors
    Margo, Curtis E.
    French, Dustin D.
    [J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 2007, 143 (03) : 538 - 539