Solid phase synthesis of 1-aminohydantoin libraries

被引：45

作者：

Wilson, LJ ^{[1
]}

Li, M ^{[1
]}

Portlock, DE ^{[1
]}

机构：

[1] Proctor & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(98)01009-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid support synthesis of a series of 1-aminohydantoins based on a diverse set of hydrazino amino acids aldehydes, and amines is described. The method involves the construction of resin attached hydrazino acid precursors, followed by subsequent derivatization, and then cyclizative cleavage off the resin. Overall yields vary per example between 15 and 60%, and the samples are suitable for biological evaluations without further purification. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5135 / 5138

页数：4

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