Advances in iron metabolism: a transition state

被引：8

作者：

Cadet, E

Gadenne, M

Capron, D

Rochette, J

机构：

[1] Univ Picardie, CHU Amiens, Serv Genet Mol Med, F-80036 Amiens, France

[2] Univ Picardie, CHU Amiens, UPRES, EA 2629, F-80036 Amiens, France

[3] INERIS, UMR, F-60750 Verneuil En Halatte, France

[4] CHU Amiens, Serv Hepatogastroenterol, F-80054 Amiens, France

来源：

REVUE DE MEDECINE INTERNE | 2005年 / 26卷 / 04期

关键词：

iron metabolism; regulation; haemochromatosis; hepcidin;

D O I：

10.1016/j.revmed.2004.09.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose. - Advances towards the understanding of gene regulation and protein function recently discovered through iron metabolism disorders are the subject of this review. Current knowledge and key points. - Within a few years the discovery of genes that determine heritable defects of cellular iron uptake or regulation in mice as in humans have provided new insights for investigation into iron metabolism pathways. Future prospects and projects. - It is still unclear how connections are made between new proteins in iron uptake, trafficking and regulation of iron homeostasis. Gene expression studies using microarrays technology in different iron conditions should help to explore iron homeostasis further. (c) 2004 Elsevier SAS. Tous droits reserves.

引用

页码：315 / 324

页数：10

共 93 条

[1] A novel mammalian iron-regulated protein involved in intracellular iron metabolism [J].