Expression of soluble interleukin-6 receptor in malignant ovarian tissue

被引：29

作者：

Rath, Kellie S. ^{[2
]}

Funk, Holly M.

Bowling, Marcia C. ^{[3
]}

Richards, William E. ^{[2
]}

Drew, Angela F. ^{[1
]}

机构：

[1] Univ Cincinnati, Sch Med, Dept Canc & Cell Biol, Vontz Ctr Mol Studies, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Sch Med, Div Gynecol Oncol, Dept Obstet & Gynecol, Cincinnati, OH 45267 USA

[3] Christ Hosp, Dept Obstet & Gynecol, Cincinnati, OH 45219 USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2010年 / 203卷 / 03期

关键词：

a disintegrin and metalloprotease domain 10; a disintegrin and metalloprotease domain 17; cytokine receptor; inflammation; interleukin-6; ovarian tumor; SIGNAL TRANSDUCER; IL-6; RECEPTOR; TNF-ALPHA; IN-VIVO; CANCER; CELLS; TUMOR; PROGRESSION; ACTIVATION; CYTOKINE;

D O I：

10.1016/j.ajog.2010.03.034

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The objective of the study was to investigate interleukin-6 receptor (IL6R) isoforms and sheddases in the ovarian tumor microenvironment. STUDY DESIGN: Expression of IL6R and sheddases was measured in tissue samples of papillary serous ovarian carcinomas and benign ovaries by real-time polymerase chain reaction and immunohistochemistry. Murine xenograft samples were tested by enzyme-linked immunosorbent assay to discriminate and evaluate tumor and host contributions of IL6R. RESULTS: IL6R expression was increased in malignant ovarian tumors and localized to epithelial cells. Expression of a soluble splice variant of IL6R was increased in malignant tumors, as were the sheddases for the full-length isoform. An in vivo xenograft model showed that host IL6R expression is also increased and regulated by tumor-associated inflammation. CONCLUSION: IL6R is overexpressed in epithelial ovarian malignancies because of increases in a soluble IL6R variant, in the sheddases for full-length IL6R and host IL6R expression. Soluble IL6R may be an efficacious target for reducing IL6-mediated ovarian tumor progression.

引用

页码：230.e1 / 230.e8

页数：8

共 40 条

[1]

[Anonymous], 2008, Cancer facts and figures

[2] TGF-β suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling [J].