Suzuki-Miyaura coupling reaction using pentafluorophenylboronic acid

被引：120

作者：

Korenaga, T ^{[1
]}

Kosaki, T ^{[1
]}

Fukumura, R ^{[1
]}

Ema, T ^{[1
]}

Sakai, T ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Nat Sci, Dept Synthet Chem, Okayama 7008530, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 22期

关键词：

D O I：

10.1021/ol051866i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] We have found new conditions for the Suzuki-Miyaura coupling reaction applicable to pentafluorophenylboronic acid (C6F5B(OH)2) (1), which is an inactive substrate under normal conditions. The reactions of 1 with phenyl iodide or bromide under Pd(PPh3)(4)/CsF/Ag2O or Pd-2(dba)(3)/P(t-Bu)(3)CsF/Ag2O catalytic system conditions gave 2,3,4,5,6-pentafluoro-1,1'-biphenyl (3a) in more than 90% yields. Combination of CsF and Ag2O was essential for promoting these reactions.

引用

页码：4915 / 4917

页数：3

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