p53 in biopsies of oral squamous cell carcinoma. A comparative study with a malignancy grading system

被引：13

作者：

DeAraujo, VC ^{[1
]}

Loyola, AM ^{[1
]}

Pinto, DDS ^{[1
]}

Borra, RC ^{[1
]}

DeAraujo, NS ^{[1
]}

机构：

[1] UNIV FED UBERLANDIA,DISCIPLINA PATAL BUCAL,BR-38400 UBERLANDIA,MG,BRAZIL

来源：

ORAL ONCOLOGY | 1997年 / 33B卷 / 01期

关键词：

oral cancer; p53; protein; malignancy grading system;

D O I：

10.1016/S0964-1955(96)00055-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The relationship between the histological grading of malignancy and p53 protein expression was studied in 40 biopsies of oral squamous cell carcinomas. An immunohistochemical analysis was carried out using the steptavidin method preceded by a treatment with citric acid in a microwave oven. All cases were classified according to the histological malignancy grading system proposed by Anneroth et al. (Scandinavian Journal of Dental Research 1987, 95, 229-249). The expression of p53 was found in 62.5% of the carcinomas studied. Positivity of p53 staining showed a correlation with the histological grade of malignancy and with the degree of keratinisation, nuclear polymorphism and number of mitoses. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：5 / 9

页数：5

共 23 条

[1]

ANNEROTH G, 1987, SCAND J DENT RES, V95, P229

[2]

Araujo VC, 1993, EUROPEAN ARCH OTARHI, V250, P105

[3] PROGNOSTIC VALUE OF VARIOUS MOLECULAR AND CELLULAR-FEATURES IN ORAL SQUAMOUS-CELL CARCINOMAS - A REVIEW [J].

BRYNE, M .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 1991, 20 (09) :413-420

[4]

ESRIG D, 1993, AM J PATHOL, V143, P1389

[5]

FIELD JK, 1993, INT J ONCOL, V3, P431

[6]

FIELDING LP, 1992, CANCER, V70, P367

[7] IMMUNOHISTOLOGICAL DETECTION OF TUMOR-GROWTH FRACTION (KI-67 ANTIGEN) IN FORMALIN-FIXED AND ROUTINELY PROCESSED TISSUES [J].

GERDES, J ;

BECKER, MHG ;

KEY, G ;

CATTORETTI, G .

JOURNAL OF PATHOLOGY, 1992, 168 (01) :85-86

[8] P53 - AT THE CROSSROADS OF MOLECULAR CARCINOGENESIS AND RISK ASSESSMENT [J].

HARRIS, CC .

SCIENCE, 1993, 262 (5142) :1980-1981

[9]

KAWAI A, 1994, CANCER, V73, P2499, DOI 10.1002/1097-0142(19940515)73:10<2499::AID-CNCR2820731008>3.0.CO

[10]

2-G

← 1 2 3 →