Reduced Avian Virulence and Viremia of West Nile Virus Isolates from Mexico and Texas

被引：31
作者：
Brault, Aaron C. [1 ]
Langevin, Stanley A. [2 ,3 ]
Ramey, Wanichaya N. [2 ,3 ]
Fang, Ying [2 ,3 ]
Beasley, David W. C. [4 ,5 ]
Barker, Christopher M. [2 ,3 ]
Sanders, Todd A. [6 ]
Reisen, William K. [2 ,3 ]
Barrett, Alan D. T. [4 ,5 ]
Bowen, Richard A. [7 ]
机构：
[1] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA
[2] Univ Calif Davis, Ctr Vector Borne Dis, Davis, CA 95616 USA
[3] Univ Calif Davis, Dept Pathol Microbiol & Immunol, Sch Vet Med, Davis, CA 95616 USA
[4] Univ Texas Med Branch, Dept Pathol, Ctr Emerging Infect Dis & Biodef, Inst Human Infect & Immun, Galveston, TX USA
[5] Univ Texas Med Branch, Dept Microbiol & Immunol, Ctr Emerging Infect Dis & Biodef, Inst Human Infect & Immun, Galveston, TX USA
[6] US Fish & Wildlife Serv, Div Migratory Bird Management, Portland, OR USA
[7] Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA
来源：
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2011年 / 85卷 / 04期
基金：
美国国家卫生研究院;
关键词：
ENVELOPE PROTEIN GLYCOSYLATION; LOUIS ENCEPHALITIS-VIRUS; SEROLOGIC EVIDENCE; NEW-YORK; AMERICAN CROWS; KUNJIN VIRUS; BIRDS; STRAINS; INFECTION; TRANSMISSION;
D O I：
10.4269/ajtmh.2011.10-0439
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
A West Nile virus (WNV) isolate from Mexico (TM171-03) and BIRD1153, a unique genotype from Texas, have exhibited reduced murine neuroinvasive phenotypes. To determine if murine neuroinvasive capacity equates to avian virulence potential, American crow (Corvus brachyrhynchos) and house sparrows (Passer domesticus) were experimentally inoculated with representative murine neuroinvasive/non-neuroinvasive strains. In both avian species, a plaque variant from Mexico that was E-glycosylation competent produced higher viremias than an E-glycosylation incompetent variant, indicating the potential importance of E-glycosylation for avian replication. The murine non-neuroinvasive BIRD1153 strain was significantly attenuated in American crows but not house sparrows when compared with the murine neuroinvasive Texas strain. Despite the loss of murine neuroinvasive properties of nonglycosylated variants from Mexico, our data indicate avian replication potential of these strains and that unique WNV virulence characteristics exist between murine and avian models. The implications of reduced avian replication of variants from Mexico for restricted WNV transmission in Latin America is discussed.
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收藏
页码：758 / 767
页数：10
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