An Efficient Four-component Synthesis of Spiro[indoline-pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine]triones

被引：12

作者：

Ghahremanzadeh, Ramin ^{[1
]}

Moghaddam, Mojtaba Mirhosseini ^{[1
]}

Bazgir, Ayoob ^{[2
]}

Akhondi, Mohammad Mehdi ^{[3
]}

机构：

[1] ACECR, Avicenna Res Inst, Nanobiotechnol Res Ctr, Tehran, Iran

[2] Shahid Beheshti Univ, GC, Dept Chem, Tehran, Iran

[3] ACECR, Avicenna Res Inst, Ctr Res Reprod, Tehran, Iran

来源：

CHINESE JOURNAL OF CHEMISTRY | 2012年 / 30卷 / 02期

关键词：

catalysis; condensation; cyclization; green chemistry; ionic liquids; multicomponent reaction; spiro compounds; ONE-POT; 3-COMPONENT SYNTHESIS; MULTICOMPONENT REACTIONS; MICROWAVE IRRADIATION; DERIVATIVES; CHEMISTRY; AGENTS; INHIBITORS; RECEPTOR; LIBRARY;

D O I：

10.1002/cjoc.201180471

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A four-component reaction in the presence of Alum [KAl(SO4)(2)center dot 12H(2)O] as an inexpensive and reusable catalyst using the ionic liquid as an effective green reaction media is reported.

引用

页码：321 / 326

页数：6

共 36 条

[1] Synthesis and evaluation of some new spiro indoline-based heterocycles as potentially active antimicrobial agents [J].

Abdel-Rahman, AH ;

Keshk, EM ;

Hanna, MA ;

El-Bady, SM .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (09) :2483-2488

[2]

[Anonymous], 1996, CHEM INDOLES

[3] Synthesis and in vitro evaluation of substituted pyrimido[5,4-d]pyrimidines as a novel class of Antimycobacterium tuberculosis agents [J].

Bacelar, Ana H. ;

Carvalho, M. Alice ;

Proenca, M. Fernanda .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (07) :3234-3239

[4]

Chiu G., 2006, PCT Int. Appl., Patent No. [2006130673, WO 2006130673]

[5] The chemistry of isatins: a review from 1975 to 1999 [J].

da Silva, JFM ;

Garden, SJ ;

Pinto, AC .

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2001, 12 (03) :273-324

[6] Efficient microwave enhanced regioselective synthesis of a series of benzimidazolyl/triazolyl spiro [indole-thiazohdinones] as potent antifungal agents and crystal structure of spiro[3H-indole-3,2′-thiazolidine]-3′(1,2,4-triazol-3-yl)-2,4′(1H)-dione [J].

Dandia, A ;

Singh, R ;

Khaturia, S ;

Mérienne, C ;

Morgant, G ;

Loupy, A .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (07) :2409-2417

[7]

de Meijere A, 1999, ANGEW CHEM INT EDIT, V38, P3669, DOI 10.1002/(SICI)1521-3773(19991216)38:24<3669::AID-ANIE3669>3.0.CO

[8]

2-X

[9] Microwave irradiation in solvent-free conditions:: an eco-friendly methodology to prepare indazoles, pyrazolopyridines and bipyrazoles by cycloaddition reactions [J].

Díaz-Ortiz, A ;

de la Hoz, A ;

Langa, F .

GREEN CHEMISTRY, 2000, 2 (04) :165-172

[10] Recent developments in isocyanide based multicomponent reactions in applied chemistry [J].

Dömling, A .

CHEMICAL REVIEWS, 2006, 106 (01) :17-89

← 1 2 3 4 →