Case-control study of patients with essential tremor in Latvia

被引：15

作者：

Inashkina, I. ^{[1
]}

Radovica, I. ^{[1
]}

Smeltere, L. ^{[2
]}

Vitols, E. ^{[3
]}

Jankevics, E. ^{[1
]}

机构：

[1] Latvian Biomed Res & Study Ctr, LV-1067 Riga, Latvia

[2] Paul Stradins Univ Clin Hosp, Riga, Latvia

[3] Riga Stradins Univ, Dept Neurol, Riga, Latvia

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2008年 / 15卷 / 09期

关键词：

case-control; essential tremor; short tandem repeat;

D O I：

10.1111/j.1468-1331.2008.02225.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known. We genotyped 16 microsatellite markers in a case-control cohort consisting of 104 patients and 116 controls. No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02-1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls. There was not a significant difference in genotypic distribution between disease group and control subjects (chi(2) = 2.8, P = 0.25).

引用

页码：988 / 990

页数：3

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