Studies on the third-generation of epidermal growth factor receptor tyrosine kinase inhibitors (EGERTKIs) targeting EGFR(L858R/T790M) mutant remain hotspots, specifically for non-small cell lung cancer (NSCLC). In the current study, a new series of EGFR-TKIs with thieno[3,2-d]pyrimidine derivatives(6a-6r) bearing quinolin-2(1H)-ones were designed and synthesized, through conformational constrained strategy from the third generation of EGFR-TKI olmutinib. In vitro structure-activity relationship (SAR) studies indicated that compounds 6a, 6l, 6m, 6n and 6o exhibited good selective inhibition to EGFR(L858R/T790M) (IC50 <= 250 nM) over wild type EGFR (IC50 > 10000 nM). The observed selectivity of compounds 6l and 6o was also proved by the computational molecular docking and the cellular thermal shift assay. These compounds had good growth inhibitory effect on the four tested cancer cell lines. Specifically, 6o could significantly inhibit the colony formation, wound healing and the expression of p-EGFR and its downstream p-ERK in EGFR(L858R/T790M) lung cancer cells. Our findings suggest that the thieno[3,2d]pyrimidine compounds, especially 6l and 6o, can selectively target the mutant EGFR(L858R/T790M) in vitro and at cellular level and may serve as the lead compounds for generating new series of the third-generation EGFR-TKIs. (C) 2020 Published by Elsevier Masson SAS.
机构:
Louisiana State Univ, Dept Hematol & Oncol, Hlth Sci Ctr, Baton Rouge, LA 70805 USA
Hematol Oncol Clin, Baton Rouge, LA USALouisiana State Univ, Dept Hematol & Oncol, Hlth Sci Ctr, Baton Rouge, LA 70805 USA
Cataldo, Vince D.
Gibbons, Don L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USALouisiana State Univ, Dept Hematol & Oncol, Hlth Sci Ctr, Baton Rouge, LA 70805 USA
Gibbons, Don L.
Perez-Soler, Roman
论文数: 0引用数: 0
h-index: 0
机构:
Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10467 USALouisiana State Univ, Dept Hematol & Oncol, Hlth Sci Ctr, Baton Rouge, LA 70805 USA
Perez-Soler, Roman
Quintas-Cardama, Alfonso
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USALouisiana State Univ, Dept Hematol & Oncol, Hlth Sci Ctr, Baton Rouge, LA 70805 USA
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Cohen, MH
Williams, GA
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Williams, GA
Sridhara, R
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Sridhara, R
Chen, G
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Chen, G
McGuinn, WD
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
McGuinn, WD
Morse, D
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Morse, D
Abraham, S
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Abraham, S
Rahman, A
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Rahman, A
Liang, CY
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Liang, CY
Lostritto, R
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Lostritto, R
Baird, A
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Baird, A
Pazdur, R
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
机构:
US FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USAUS FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
Cohen, MH
Johnson, JR
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USAUS FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
Johnson, JR
Chen, YF
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USAUS FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
Chen, YF
Sridhara, R
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USAUS FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
Sridhara, R
Pazdur, R
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USAUS FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Jia, Yong
Yun, Cai-Hong
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA
Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
Peking Univ, Inst Syst Biomed, Beijing 100191, Peoples R China
Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100191, Peoples R ChinaNovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Yun, Cai-Hong
Park, Eunyoung
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA
Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Park, Eunyoung
Rcan, Dalia E.
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Rcan, Dalia E.
Manuia, Mari
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Manuia, Mari
Juarez, Jose
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Juarez, Jose
Xu, Chunxiao
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Xu, Chunxiao
Rhee, Kevin
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Rhee, Kevin
Chen, Ting
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Chen, Ting
Zhang, Haikuo
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Zhang, Haikuo
Palakurthi, Sangeetha
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Belfer Ctr Appl Canc Sci, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Palakurthi, Sangeetha
Jang, Jaebong
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA
Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Jang, Jaebong
Lelais, Gerald
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Lelais, Gerald
DiDonato, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
DiDonato, Michael
Bursulaya, Badry
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Bursulaya, Badry
Michellys, Pierre-Yves
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Michellys, Pierre-Yves
Epple, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Epple, Robert
Marsilje, Thomas H.
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Marsilje, Thomas H.
McNeill, Matthew
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
McNeill, Matthew
Lu, Wenshuo
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Lu, Wenshuo
Harris, Jennifer
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Harris, Jennifer
Bender, Steven
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Bender, Steven
Wong, Kwok-Kin
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USA
Dana Farber Canc Inst, Belfer Ctr Appl Canc Sci, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Wong, Kwok-Kin
Janne, Pasi A.
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USA
Dana Farber Canc Inst, Belfer Ctr Appl Canc Sci, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Janne, Pasi A.
Eck, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA
Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
机构:
Louisiana State Univ, Dept Hematol & Oncol, Hlth Sci Ctr, Baton Rouge, LA 70805 USA
Hematol Oncol Clin, Baton Rouge, LA USALouisiana State Univ, Dept Hematol & Oncol, Hlth Sci Ctr, Baton Rouge, LA 70805 USA
Cataldo, Vince D.
Gibbons, Don L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USALouisiana State Univ, Dept Hematol & Oncol, Hlth Sci Ctr, Baton Rouge, LA 70805 USA
Gibbons, Don L.
Perez-Soler, Roman
论文数: 0引用数: 0
h-index: 0
机构:
Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10467 USALouisiana State Univ, Dept Hematol & Oncol, Hlth Sci Ctr, Baton Rouge, LA 70805 USA
Perez-Soler, Roman
Quintas-Cardama, Alfonso
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USALouisiana State Univ, Dept Hematol & Oncol, Hlth Sci Ctr, Baton Rouge, LA 70805 USA
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Cohen, MH
Williams, GA
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Williams, GA
Sridhara, R
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Sridhara, R
Chen, G
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Chen, G
McGuinn, WD
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
McGuinn, WD
Morse, D
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Morse, D
Abraham, S
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Abraham, S
Rahman, A
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Rahman, A
Liang, CY
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Liang, CY
Lostritto, R
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Lostritto, R
Baird, A
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
Baird, A
Pazdur, R
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USAUS FDA, Div Oncol Drug Prod, Ctr Drug Evaluat & res, Rockville, MD 20857 USA
机构:
US FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USAUS FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
Cohen, MH
Johnson, JR
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USAUS FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
Johnson, JR
Chen, YF
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USAUS FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
Chen, YF
Sridhara, R
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USAUS FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
Sridhara, R
Pazdur, R
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USAUS FDA, HFD 150, Div Oncol Drug Prod, Ctr Drug Evaluat & Res, Rockville, MD 20857 USA
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Jia, Yong
Yun, Cai-Hong
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA
Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
Peking Univ, Inst Syst Biomed, Beijing 100191, Peoples R China
Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100191, Peoples R ChinaNovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Yun, Cai-Hong
Park, Eunyoung
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA
Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Park, Eunyoung
Rcan, Dalia E.
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Rcan, Dalia E.
Manuia, Mari
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Manuia, Mari
Juarez, Jose
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Juarez, Jose
Xu, Chunxiao
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Xu, Chunxiao
Rhee, Kevin
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Rhee, Kevin
Chen, Ting
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Chen, Ting
Zhang, Haikuo
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Zhang, Haikuo
Palakurthi, Sangeetha
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Belfer Ctr Appl Canc Sci, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Palakurthi, Sangeetha
Jang, Jaebong
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA
Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Jang, Jaebong
Lelais, Gerald
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Lelais, Gerald
DiDonato, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
DiDonato, Michael
Bursulaya, Badry
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Bursulaya, Badry
Michellys, Pierre-Yves
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Michellys, Pierre-Yves
Epple, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Epple, Robert
Marsilje, Thomas H.
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Marsilje, Thomas H.
McNeill, Matthew
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
McNeill, Matthew
Lu, Wenshuo
论文数: 0引用数: 0
h-index: 0
机构:
Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Lu, Wenshuo
Harris, Jennifer
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Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Harris, Jennifer
Bender, Steven
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Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Bender, Steven
Wong, Kwok-Kin
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Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USA
Dana Farber Canc Inst, Belfer Ctr Appl Canc Sci, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Wong, Kwok-Kin
Janne, Pasi A.
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Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02215 USA
Dana Farber Canc Inst, Belfer Ctr Appl Canc Sci, Boston, MA 02215 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
Janne, Pasi A.
Eck, Michael J.
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Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA
Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USANovartis Res Fdn, Genom Inst, San Diego, CA 92121 USA