Decreased expression of lncRNA VPS9D1-AS1 in gastric cancer and its clinical significance

被引：46
作者：
Chen, Min [1 ]
Wu, Xiaoliang [2 ,3 ,4 ]
Ma, Wenjuan [3 ,4 ]
Zhou, Qianghua [3 ,4 ]
Wang, Xing [3 ,4 ]
Zhang, Rongxin [3 ,4 ]
Wang, Jiahong [3 ,4 ,5 ]
Yang, Xianzi [3 ,4 ,5 ]
机构：
[1] Zunyi Med Coll, Dept Oncol, Affiliated Hosp, Zunyi, Guizhou, Peoples R China
[2] Guizhou Prov Peoples Hosp, Dept Oncol, Guiyang, Guizhou, Peoples R China
[3] Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China
[5] Guangzhou Med Univ, Affiliated Canc Hosp & Inst, Guangzhou, Guangdong, Peoples R China
来源：
CANCER BIOMARKERS | 2018年 / 21卷 / 01期
关键词：
Long non-coding RNA; VPS9D1-AS1; gastric cancer; downregulation; LONG NONCODING RNA; MODULAR SCAFFOLD; STATISTICS; BINDING;
D O I：
10.3233/CBM-170172
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: A recent study has demonstrated that the long non-coding RNA VPS9D1-AS1 is highly expressed in colorectal cancer and predicts poor prognosis. However, roles of VPS9D1-AS1 in gastric cancer remained poorly understood. OBJECTIVE: The aim of this study is to decipher the expression of VPS9D1-AS1 in gastric cancer (GC) patients, so as to assess whether or not it could be used as a novel biomarker for prognosis in gastric cancer patients. METHODS: The expression of VPS9D1-AS1 was examined in cancer tissues and paired adjacent non-tumorous tissues from 126 gastric cancer patients using qRT-PCR. Correlations between the expression of VPS9D1-AS1 and clinicopathological parameters and patients' survival were analyzed. RESULTS: VPS9D1-AS1 expression was downregulated in gastric cancer tissues than that in adjacent non-tumorous tissues (P < 0.001). VPS9D1-AS1 expression level was markedly correlated with tumor size and TNM stage in gastric cancer. Kaplan-Meier analysis showed low expression of VPS9D1-AS1 were correlated with poor overall and disease free survival. On multivariate analysis, the hazard ratio of VPS9D1-AS expression was 0.30 (95% CI = 0.13-0.66, P = 0.003) for overall survival. CONCLUSIONS: Overall, our data suggest that downregulated VPS9D1-AS1 may be used as a novel prognosis predictor of gastric cancer.
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页码：23 / 28
页数：6
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