共 84 条
Chemical analysis of multicellular tumour spheroids
被引:44
作者:

Jamieson, L. E.
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机构:
Univ Edinburgh, Sch Chem, EaStCHEM, Edinburgh EH9 3JJ, Midlothian, Scotland Univ Edinburgh, Sch Chem, EaStCHEM, Edinburgh EH9 3JJ, Midlothian, Scotland

Harrison, D. J.
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机构:
Univ St Andrews, St Andrews KY16 9TF, Fife, Scotland Univ Edinburgh, Sch Chem, EaStCHEM, Edinburgh EH9 3JJ, Midlothian, Scotland

Campbell, C. J.
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h-index: 0
机构:
Univ Edinburgh, Sch Chem, EaStCHEM, Edinburgh EH9 3JJ, Midlothian, Scotland Univ Edinburgh, Sch Chem, EaStCHEM, Edinburgh EH9 3JJ, Midlothian, Scotland
机构:
[1] Univ Edinburgh, Sch Chem, EaStCHEM, Edinburgh EH9 3JJ, Midlothian, Scotland
[2] Univ St Andrews, St Andrews KY16 9TF, Fife, Scotland
来源:
关键词:
LIGHT-SHEET MICROSCOPY;
PROTEIN EXPRESSION;
HYPOXIC CELLS;
IN-VITRO;
EXTRACELLULAR-MATRIX;
MASS-SPECTROMETRY;
LIVE CELLS;
CULTURE;
PH;
GROWTH;
D O I:
10.1039/c5an00524h
中图分类号:
O65 [分析化学];
学科分类号:
070302 ;
081704 ;
摘要:
Conventional two dimensional (2D) monolayer cell culture has been considered the 'gold standard' technique for in vitro cellular experiments. However, the need for a model that better mimics the three dimensional (3D) architecture of tissue in vivo has led to the development of Multicellular Tumour Spheroids (MTS) as a 3D tissue culture model. To some extent MTS mimic the environment of in vivo tumours where, for example, oxygen and nutrient gradients develop, protein expression changes and cells form a spherical structure with regions of proliferation, senescence and necrosis. This review focuses on the development of techniques for chemical analysis of MTS as a tool for understanding in vivo tumours and a platform for more effective drug and therapy discovery. While traditional monolayer techniques can be translated to 3D models, these often fail to provide the desired spatial resolution and z-penetration for live cell imaging. More recently developed techniques for overcoming these problems will be discussed with particular reference to advances in instrument technology for achieving the increased spatial resolution and imaging depth required.
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页码:3910 / 3920
页数:11
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