NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity

被引：19

作者：

Godkowicz, Magdalena ^{[1
,2
]}

Druszczynska, Magdalena ^{[2
]}

机构：

[1] Univ Lodz, Lodz Inst, BioMed Chem Doctoral Sch, Polish Acad Sci, PL-90237 Lodz, Poland

[2] Univ Lodz, Fac Biol & Environm Protect, Dept Immunol & Infect Biol, Banacha12-16, PL-90237 Lodz, Poland

来源：

VACCINES | 2022年 / 10卷 / 09期

关键词：

NLR; antimicrobial immunity; ssRNA virus; NF-KAPPA-B; MYCOBACTERIUM-TUBERCULOSIS INFECTION; FAMILY-MEMBER NLRC5; TOLL-LIKE RECEPTORS; CLASS-I EXPRESSION; NUCLEOTIDE OLIGOMERIZATION; NEUTROPHIL RECRUITMENT; MURAMYL DIPEPTIDE; BINDING DOMAIN; RIG-I;

D O I：

10.3390/vaccines10091487

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The innate immune system recognizes pathogen-associated molecular motifs through pattern recognition receptors (PRRs) that induce inflammasome assembly in macrophages and trigger signal transduction pathways, thereby leading to the transcription of inflammatory cytokine genes. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) represent a family of cytosolic PRRs involved in the detection of intracellular pathogens such as mycobacteria or viruses. In this review, we discuss the role of NOD1, NOD2, and NLRC5 receptors in regulating antiviral and antimycobacterial immune responses by providing insight into molecular mechanisms as well as their potential health and disease implications.

引用

页数：18

共 149 条

[81] Modulation of Nod2-dependent NF-κB signaling by the actin cytoskeleton [J].

Legrand-Poels, Sylvie ;

Kustermans, Gaelle ;

Bex, Francoise ;

Kremmer, Elisabeth ;

Kufer, Thomas A. ;

Piette, Jacques .

JOURNAL OF CELL SCIENCE, 2007, 120 (07) :1299-1310

[82] Specificity and expression of CIITA, the master regulator of MHC class II genes [J].

LeibundGut-Landmann, S ;

Waldburger, JM ;

Krawczyk, M ;

Otten, LA ;

Suter, T ;

Fontana, A ;

Acha-Orbea, H ;

Reith, W .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (06) :1513-1525

[83] Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population [J].

Leturiondo, Andre Luiz ;

Noronha, Ariani Batista ;

Ribeiro Mendonca, Carla Yael ;

Ferreira, Cynthia de Oliveira ;

Alvarado-Arnez, Lucia Elena ;

de Neves Manta, Fernanda Saloum ;

de Lima Bezerra, Ohanna Cavalcanti ;

de Carvalho, Elizeu Fagundes ;

Moraes, Milton Ozorio ;

Rodrigues, Fabiola da Costa ;

Talhari, Carolina .

PLOS NEGLECTED TROPICAL DISEASES, 2020, 14 (05) :1-13

[84] Regulation of IL-8 and IL-1β expression in Crohn's disease associated NOD2/CARD15 mutations [J].

Li, J ;

Moran, T ;

Swanson, E ;

Julian, C ;

Harris, J ;

Bonen, DK ;

Hedl, M ;

Nicolae, DL ;

Abraham, C ;

Cho, JH .

HUMAN MOLECULAR GENETICS, 2004, 13 (16) :1715-1725

[85] Nodosome Inhibition as a Novel Broad-Spectrum Antiviral Strategy against Arboviruses, Enteroviruses, and SARS-CoV-2 [J].

Limonta, Daniel ;

Dyna-Dagman, Lovely ;

Branton, William ;

Mancinelli, Valeria ;

Makio, Tadashi ;

Wozniak, Richard W. ;

Power, Christopher ;

Hobman, Tom C. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 65 (08)

[86] DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses [J].

Lipinski, Simone ;

Till, Andreas ;

Sina, Christian ;

Arlt, Alexander ;

Grasberger, Helmut ;

Schreiber, Stefan ;

Rosenstiel, Philip .

JOURNAL OF CELL SCIENCE, 2009, 122 (19) :3522-3530

[87] Palmitoylation of NOD1 and NOD2 is required for bacterial sensing [J].

Lu, Yan ;

Zheng, Yuping ;

Coyaud, Etienne ;

Zhang, Chao ;

Selvabaskaran, Apiraam ;

Yu, Yuyun ;

Xu, Zizhen ;

Weng, Xialian ;

Chen, Ji Shun ;

Meng, Ying ;

Warner, Neil ;

Cheng, Xiawei ;

Liu, Yangyang ;

Yao, Bingpeng ;

Hu, Hu ;

Xia, Zonping ;

Muise, Aleixo M. ;

Klip, Amira ;

Brumell, John H. ;

Girardin, Stephen E. ;

Ying, Songmin ;

Fairn, Gregory D. ;

Raught, Brian ;

Sun, Qiming ;

Neculai, Dante .

SCIENCE, 2019, 366 (6464) :460-+

[88] Nucleotide Oligomerization and Binding Domain 2-Dependent Dendritic Cell Activation Is Necessary for Innate Immunity and Optimal CD8+ T Cell Responses to Influenza A Virus Infection [J].

Lupfer, Christopher ;

Thomas, Paul G. ;

Kanneganti, Thirumala-Devi .

JOURNAL OF VIROLOGY, 2014, 88 (16) :8946-8955

[89] The expanding role of NLRs in antiviral immunity [J].

Lupfer, Christopher ;

Kanneganti, Thirumala-Devi .

IMMUNOLOGICAL REVIEWS, 2013, 255 (01) :13-24

[90] Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8+ T Cell Function and Impaired Viral Clearance [J].

Lupfer, Christopher R. ;

Stokes, Kate L. ;

Kuriakose, Teneema ;

Kanneganti, Thirumala-Devi .

JOURNAL OF VIROLOGY, 2017, 91 (17)

← 4 5 6 7 8 9 10 11 12 13 →