NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity

被引：19

作者：

Godkowicz, Magdalena ^{[1
,2
]}

Druszczynska, Magdalena ^{[2
]}

机构：

[1] Univ Lodz, Lodz Inst, BioMed Chem Doctoral Sch, Polish Acad Sci, PL-90237 Lodz, Poland

[2] Univ Lodz, Fac Biol & Environm Protect, Dept Immunol & Infect Biol, Banacha12-16, PL-90237 Lodz, Poland

来源：

VACCINES | 2022年 / 10卷 / 09期

关键词：

NLR; antimicrobial immunity; ssRNA virus; NF-KAPPA-B; MYCOBACTERIUM-TUBERCULOSIS INFECTION; FAMILY-MEMBER NLRC5; TOLL-LIKE RECEPTORS; CLASS-I EXPRESSION; NUCLEOTIDE OLIGOMERIZATION; NEUTROPHIL RECRUITMENT; MURAMYL DIPEPTIDE; BINDING DOMAIN; RIG-I;

D O I：

10.3390/vaccines10091487

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The innate immune system recognizes pathogen-associated molecular motifs through pattern recognition receptors (PRRs) that induce inflammasome assembly in macrophages and trigger signal transduction pathways, thereby leading to the transcription of inflammatory cytokine genes. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) represent a family of cytosolic PRRs involved in the detection of intracellular pathogens such as mycobacteria or viruses. In this review, we discuss the role of NOD1, NOD2, and NLRC5 receptors in regulating antiviral and antimycobacterial immune responses by providing insight into molecular mechanisms as well as their potential health and disease implications.

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页数：18

相关论文

共 149 条

[41] Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan [J].

Girardin, SE ;

Boneca, IG ;

Carneiro, LAM ;

Antignac, A ;

Jéhanno, M ;

Viala, J ;

Tedin, K ;

Taha, MK ;

Labigne, A ;

Zähringer, U ;

Coyle, AJ ;

Bertin, J ;

Sansonetti, PJ ;

Philpott, DJ .

SCIENCE, 2003, 300 (5625) :1584-1587

[42] Crohn's Disease Susceptibility Genes are Associated With Leprosy in the Vietnamese Population [J].

Grant, Audrey V. ;

Alter, Andrea ;

Nguyen Thu Huong ;

Orlova, Marianna ;

Nguyen Van Thuc ;

Nguyen Ngoc Ba ;

Vu Hong Thai ;

Abel, Laurent ;

Schurr, Erwin ;

Alcais, Alexandre .

JOURNAL OF INFECTIOUS DISEASES, 2012, 206 (11) :1763-1767

[43] The Innate Immune Protein Nod2 Binds Directly to MDP, a Bacterial Cell Wall Fragment [J].

Grimes, Catherine Leimkuhler ;

Ariyananda, Lushanti De Zoysa ;

Melnyk, James E. ;

O'Shea, Erin K. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (33) :13535-13537

[44] Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells [J].

Guo, Xuancheng ;

Liu, Taixiang ;

Shi, Hengfei ;

Wang, Jingjing ;

Ji, Ping ;

Wang, Hongwei ;

Hou, Yayi ;

Tan, Ren Xiang ;

Li, Erguang .

JOURNAL OF VIROLOGY, 2015, 89 (15) :7636-7645

[45] Polymorphisms in TICAM2 and IL1B are associated with TB [J].

Hall, N. B. ;

Igo, R. P., Jr. ;

Malone, L. L. ;

Truitt, B. ;

Schnell, A. ;

Tao, L. ;

Okware, B. ;

Nsereko, M. ;

Chervenak, K. ;

Lancioni, C. ;

Hawn, T. R. ;

Mayanja-Kizza, H. ;

Joloba, M. L. ;

Boom, W. H. ;

Stein, C. M. .

GENES AND IMMUNITY, 2015, 16 (02) :127-133

[46] Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments [J].

Hasegawa, Mizuho ;

Yang, Kangkang ;

Hashimoto, Masahito ;

Park, Jong-Hwan ;

Kim, Yun-Gi ;

Fujimoto, Yukari ;

Nunez, Gabriel ;

Fukase, Koichi ;

Inohara, Naohiro .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (39) :29054-29063

[47] Nucleotide-Binding Oligomerization Domain 1 Mediates Recognition of Clostridium difficile and Induces Neutrophil Recruitment and Protection against the Pathogen [J].

Hasegawa, Mizuho ;

Yamazaki, Takashi ;

Kamada, Nobuhiko ;

Tawaratsumida, Kazuki ;

Kim, Yun-Gi ;

Nunez, Gabriel ;

Inohara, Naohiro .

JOURNAL OF IMMUNOLOGY, 2011, 186 (08) :4872-4880

[48] NLRC5 promotes cell proliferation via regulating the AKT/VEGF-A signaling pathway in hepatocellular carcinoma [J].

He, Ying-hua ;

Li, Ming-fang ;

Zhang, Xing-yan ;

Meng, Xiao-ming ;

Huang, Cheng ;

Li, Jun .

TOXICOLOGY, 2016, 359 :47-57

[49] Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challenge [J].

Hilligan, Kerry L. ;

Namasivayam, Sivaranjani ;

Clancy, Chad S. ;

O'Mard, Danielle ;

Oland, Sandra D. ;

Robertson, Shelly J. ;

Baker, Paul J. ;

Castro, Ehydel ;

Garza, Nicole L. ;

Lafont, Bernard A. P. ;

Johnson, Reed ;

Ronchese, Franca ;

Mayer-Barber, Katrin D. ;

Best, Sonja M. ;

Sher, Alan .

JOURNAL OF EXPERIMENTAL MEDICINE, 2021, 219 (02)

[50] CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells [J].

Hisamatsu, T ;

Suzuki, M ;

Reinecker, HC ;

Nadeau, WJ ;

McCormick, BA ;

Podolsky, DK .

GASTROENTEROLOGY, 2003, 124 (04) :993-1000

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