NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity

被引：19
作者：
Godkowicz, Magdalena [1 ,2 ]
Druszczynska, Magdalena [2 ]
机构：
[1] Univ Lodz, Lodz Inst, BioMed Chem Doctoral Sch, Polish Acad Sci, PL-90237 Lodz, Poland
[2] Univ Lodz, Fac Biol & Environm Protect, Dept Immunol & Infect Biol, Banacha12-16, PL-90237 Lodz, Poland
来源：
VACCINES | 2022年 / 10卷 / 09期
关键词：
NLR; antimicrobial immunity; ssRNA virus; NF-KAPPA-B; MYCOBACTERIUM-TUBERCULOSIS INFECTION; FAMILY-MEMBER NLRC5; TOLL-LIKE RECEPTORS; CLASS-I EXPRESSION; NUCLEOTIDE OLIGOMERIZATION; NEUTROPHIL RECRUITMENT; MURAMYL DIPEPTIDE; BINDING DOMAIN; RIG-I;
D O I：
10.3390/vaccines10091487
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The innate immune system recognizes pathogen-associated molecular motifs through pattern recognition receptors (PRRs) that induce inflammasome assembly in macrophages and trigger signal transduction pathways, thereby leading to the transcription of inflammatory cytokine genes. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) represent a family of cytosolic PRRs involved in the detection of intracellular pathogens such as mycobacteria or viruses. In this review, we discuss the role of NOD1, NOD2, and NLRC5 receptors in regulating antiviral and antimycobacterial immune responses by providing insight into molecular mechanisms as well as their potential health and disease implications.
引用
收藏
页数：18
相关论文
共 149 条
[1]   The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO [J].
Abbott, DW ;
Wilkins, A ;
Asara, JM ;
Cantley, LC .
CURRENT BIOLOGY, 2004, 14 (24) :2217-2227
[2]   CIITA-Driven MHC Class II Expressing Tumor Cells as Antigen Presenting Cell Performers: Toward the Construction of an Optimal Anti-tumor Vaccine [J].
Accolla, Roberto S. ;
Ramia, Elise ;
Tedeschi, Alessandra ;
Forlani, Greta .
FRONTIERS IN IMMUNOLOGY, 2019, 10
[3]   Type I Interferons Are Involved in the Intracellular Growth Control of Mycobacterium abscessus by Mediating NOD2-Induced Production of Nitric Oxide in Macrophages [J].
Ahn, Jae-Hun ;
Park, Ji-Yeon ;
Kim, Dong-Yeon ;
Lee, Tae-Sung ;
Jung, Do-Hyeon ;
Kim, Yeong-Jun ;
Lee, Yeon-Ji ;
Lee, Yun-Ji ;
Seo, In-Su ;
Song, Eun-Jung ;
Jang, Ah-Ra ;
Yang, Soo-Jin ;
Shin, Sung Jae ;
Park, Jong-Hwan .
FRONTIERS IN IMMUNOLOGY, 2021, 12
[4]   Nucleotide Oligomerization Domain 1 Enhances IFN-γ Signaling in Gastric Epithelial Cells during Helicobacter pylori Infection and Exacerbates Disease Severity [J].
Allison, Cody C. ;
Ferrand, Jonathan ;
McLeod, Louise ;
Hassan, Mohammad ;
Kaparakis-Liaskos, Maria ;
Grubman, Alexandra ;
Bhathal, Prithi S. ;
Dev, Anouk ;
Sievert, William ;
Jenkins, Brendan J. ;
Ferrero, Richard L. .
JOURNAL OF IMMUNOLOGY, 2013, 190 (07) :3706-3715
[5]   Helicobacter pylori Induces MAPK Phosphorylation and AP-1 Activation via a NOD1-Dependent Mechanism [J].
Allison, Cody C. ;
Kufer, Thomas A. ;
Kremmer, Elisabeth ;
Kaparakis, Maria ;
Ferrero, Richard L. .
JOURNAL OF IMMUNOLOGY, 2009, 183 (12) :8099-8109
[6]   Long-term in vitro and in vivo effects of γ-irradiated BCG on innate and adaptive immunity [J].
Arts, Rob J. W. ;
Blok, Bastiaan A. ;
Aaby, Peter ;
Joosten, Leo A. B. ;
de Jong, Dirk ;
van der Meer, Jos W. M. ;
Benn, Christine Stabell ;
van Crevel, Reinout ;
Netea, Mihai G. .
JOURNAL OF LEUKOCYTE BIOLOGY, 2015, 98 (06) :995-1001
[7]   Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans [J].
Austin, Celest M. ;
Ma, Xin ;
Graviss, Edward A. .
JOURNAL OF INFECTIOUS DISEASES, 2008, 197 (12) :1713-1716
[8]   GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells [J].
Barnich, N ;
Hisamatsu, T ;
Aguirre, JE ;
Xavier, R ;
Reinecker, HC ;
Podolsky, DK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (19) :19021-19026
[9]   Inflammasomes: current understanding and open questions [J].
Bauernfeind, Franz ;
Ablasser, Andrea ;
Bartok, Eva ;
Kim, Sarah ;
Schmid-Burgk, Jonathan ;
Cavlar, Taner ;
Hornung, Veit .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2011, 68 (05) :765-783
[10]   NLRC5 Limits the Activation of Inflammatory Pathways [J].
Benko, Szilvia ;
Magalhaes, Joao G. ;
Philpott, Dana J. ;
Girardin, Stephen E. .
JOURNAL OF IMMUNOLOGY, 2010, 185 (03) :1681-1691
12345678910