The Role of the Immune Checkpoint Molecules PD-1/PD-L1 and TIM-3/Gal-9 in the Pathogenesis of Preeclampsia-A Narrative Review

被引：20

作者：

Mittelberger, Johanna ^{[1
]}

Seefried, Marina ^{[1
]}

Franitza, Manuela ^{[1
]}

Garrido, Fabian ^{[1
]}

Ditsch, Nina ^{[1
]}

Jeschke, Udo ^{[1
]}

Dannecker, Christian ^{[1
]}

机构：

[1] Univ Hosp Augsburg, Dept Obstet & Gynecol, Stenglinstr 2, D-86156 Augsburg, Germany

来源：

MEDICINA-LITHUANIA | 2022年 / 58卷 / 02期

关键词：

preeclampsia; immune checkpoint molecules; PD-1; PD-L1; TIM-3; Gal-9; CELL IMMUNOGLOBULIN MUCIN-3; T-CELLS; PD-1; PATHWAY; EXPRESSION; TOLERANCE; PREGNANCY; TIM-3; PDL1; LINK;

D O I：

10.3390/medicina58020157

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Preeclampsia is a pregnancy-specific disease which is characterized by abnormal placentation, endothelial dysfunction, and systemic inflammation. Several studies have shown that the maternal immune system, which is crucial for maintaining the pregnancy by ensuring maternal-fetal-tolerance, is disrupted in preeclamptic patients. Besides different immune cells, immune checkpoint molecules such as the programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1 system) and the T-cell immunoglobulin and mucin domain-containing protein 3/Galectin-9 (TIM-3/Gal-9 system) are key players in upholding the balance between pro-inflammatory and anti-inflammatory signals. Therefore, a clear understanding about the role of these immune checkpoint molecules in preeclampsia is essential. This review discusses the role of these two immune checkpoint systems in pregnancy and their alterations in preeclampsia.

引用

页数：12

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