Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference

被引：35

作者：

Xue, Xuan ^{[2
]}

Pasparakis, George ^{[2
]}

Halliday, Nigel ^{[3
]}

Winzer, Klaus ^{[3
]}

Howdle, Steven M. ^{[4
]}

Cramphorn, Christopher J. ^{[5
,6
]}

Cameron, Neil R. ^{[5
,6
]}

Gardner, Paul M. ^{[1
]}

Davis, Benjamin G. ^{[1
]}

Fernandez-Trillo, Francisco ^{[2
]}

Alexander, Cameron ^{[2
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

[2] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

[3] Univ Nottingham, Sch Mol Med Sci, Ctr Biomol Sci, Nottingham NG7 2RD, England

[4] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[5] Univ Durham, Univ Sci Labs, Biophys Sci Inst, Durham DH1 3LE, England

[6] Univ Durham, Univ Sci Labs, Dept Chem, Durham DH1 3LE, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 42期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

cell adhesion; luminescence; polymers; quorum sensing; therapeutics; BINDING; COMMUNICATION; AGGREGATION; TALKING; SIGNAL;

D O I：

10.1002/anie.201103130

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals (see picture). The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9852 / 9856

页数：5

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