Chronic parkinsonian syndrome after 10 years of repeated insecticide spraying

被引：1

作者：

Aubeneau, L. ^{[1
]}

Bohu, P. A. ^{[1
]}

Hannequin, D. ^{[1
,2
]}

Maltete, D. ^{[1
,2
]}

机构：

[1] CHU Rouen Charles Nicolle, Dept Neurol, F-76031 Rouen, France

[2] INSERM, Fac Med, U614, F-76183 Rouen, France

来源：

REVUE NEUROLOGIQUE | 2008年 / 164卷 / 04期

关键词：

parkinsonian disorders; pesticides; insecticides; poisoning;

D O I：

10.1016/j.neurol.2007.08.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction. - Acute and reversible parkinsonism is usually described after massive ingestion of organophosphate insecticides whereas acute intoxications occurring after pesticide spraying are rare. Case report. - We report one case of atypical parkinsonian disorder following repeated spraying with an aerosol insecticide containing pyrethre and organophosphate. This patient had a daily massive dermal and respiratory exposure to these pesticides for 10 years. Cerebral MRI was normal. DAT-scan showed a presynaptic loss of function. Conclusion. - Pesticides are suspected to be one risk factor responsible for parkinsonism. The present case supports this environmental hypothesis. (C) 2007 Elsevier Masson SAS. Tous droits reserves.

引用

页码：374 / 376

页数：3

共 15 条

[1] Acute and reversible parkinsonism due to organophosphate pesticide intoxication - Five cases [J].

Bhatt, MH ;

Elias, MA ;

Mankodi, AK .

NEUROLOGY, 1999, 52 (07) :1467-1471

[2]

Brahmi N, 2004, VET HUM TOXICOL, V46, P187

[3] Epidemiology of multiple system atrophy: A prevalence and pilot risk factor study in Aquitaine, France [J].

Chrysostome, V ;

Tison, F ;

Yekhlef, F ;

Sourgen, C ;

Baldi, I ;

Dartigues, JF .

NEUROEPIDEMIOLOGY, 2004, 23 (04) :201-208

[4] Pyrethroid pesticide-induced alterations in dopamine transporter function [J].

Elwan, MA ;

Richardson, JR ;

Guillot, TS ;

Caudle, WM ;

Miller, GW .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2006, 211 (03) :188-197

[5] Oral and dermal exposure to propetamphos: a human volunteer study [J].

Garfitt, SJ ;

Jones, K ;

Mason, HJ ;

Cocker, J .

TOXICOLOGY LETTERS, 2002, 134 (1-3) :115-118

[6] Searching for a relationship between manganese and welding and Parkinson's disease [J].

Jankovic, J .

NEUROLOGY, 2005, 64 (12) :2021-2028

[7] Association of pesticide exposure with neurologic dysfunction and disease [J].

Kamel, F ;

Hoppin, JA .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2004, 112 (09) :950-958

[8] Striatal dopaminergic pathways as a target for the insecticides permethrin and chlorpyrifos [J].

Karen, DJ ;

Li, W ;

Harp, PR ;

Gillette, JS ;

Bloomquist, JR .

NEUROTOXICOLOGY, 2001, 22 (06) :811-817

[9] Pesticides and Parkinson's disease [J].

Le Couteur, DG ;

McLean, AJ ;

Taylor, MC ;

Woodham, BL ;

Board, PG .

BIOMEDICINE & PHARMACOTHERAPY, 1999, 53 (03) :122-130

[10] Association between human paraoxonase gene polymorphism and chronic symptoms in pesticide-exposed workers [J].

Lee, BW ;

London, L ;

Paulauskis, J ;

Myers, J ;

Christiani, DC .

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 2003, 45 (02) :118-122

← 1 2 →