Immune Regulation of Heme Oxygenase-1 in Allergic Airway Inflammation

被引：9
|
作者：
Xia, Zhenwei [1 ]
Zhong, Wenwei [2 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Pediat, Ruijin Hosp, Sch Med, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
[2] Shanghai Jiao Tong Univ, Dept Pediat, Xinhua Hosp, Sch Med, 1665 Kongjiang Rd, Shanghai 200090, Peoples R China
来源：
ANTIOXIDANTS | 2022年 / 11卷 / 03期
基金：
中国国家自然科学基金;
关键词：
heme oxygenase-1; asthma; airway inflammation; immunoregulation; DENDRITIC CELL MATURATION; EXHALED CARBON-MONOXIDE; T-CELLS; UP-REGULATION; ANTIGEN PRESENTATION; PROTECTIVE ROLE; MOUSE MODEL; MAST-CELLS; ACTIVATION; EXPRESSION;
D O I：
10.3390/antiox11030465
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heme oxygenase-1 (HO-1) is not only a rate-limiting enzyme in heme metabolism but is also regarded as a protective protein with an immunoregulation role in asthmatic airway inflammation. HO-1 exerts an anti-inflammation role in different stages of airway inflammation via regulating various immune cells, such as dendritic cells, mast cells, basophils, T cells, and macrophages. In addition, the immunoregulation role of HO-1 may differ according to subcellular locations.
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页数：13
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