L-carnitine ameliorates dyslipidemic and hepatic disorders induced by a high-fat diet via regulating lipid metabolism, self-antioxidant capacity, and inflammatory response

被引：35

作者：

Su, Chang-Chao ^{[1
]}

Chang, Chaung-Sung ^{[2
]}

Chou, Chung-Hsi ^{[3
,4
]}

Wu, Yi-Hsieng Samuel ^{[2
]}

Yang, Kuo-Tai ^{[2
]}

Tseng, Jung-Kai ^{[5
]}

Chang, Yuan-Yen ^{[6
,7
]}

Chen, Yi-Chen ^{[2
,4
]}

机构：

[1] Chia Yi Christian Hosp, Dept Internal Med, Chiayi 600, Taiwan

[2] Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei 106, Taiwan

[3] Natl Taiwan Univ, Sch Vet Med, Taipei 106, Taiwan

[4] Natl Taiwan Univ, Zoonoses Res Ctr, Taipei 106, Taiwan

[5] Chung Shan Med Univ, Sch Optometry, Taichung 402, Taiwan

[6] Chung Shan Med Univ, Sch Med, Inst Microbiol & Immunol, Dept Microbiol & Immunol, Taichung 402, Taiwan

[7] Chung Shan Med Univ Hosp, Clin Lab, Taichung 402, Taiwan

来源：

JOURNAL OF FUNCTIONAL FOODS | 2015年 / 15卷

关键词：

Antioxidant effect; High-fat diet; L-carnitine; Lipid homeostasis; Non-alcoholic fatty liver disease; Serum lipid; GROWTH-PERFORMANCE; BETA-OXIDATION; LIVER; RATS; STEATOSIS; ENZYME;

D O I：

10.1016/j.jff.2015.04.007

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The cardiovascular and liver protection of carnitine (CNT) in a high-fat diet was investigated. Male C57BL/6 mice were divided randomly into four groups: 1) CON: Control, 2) HFD: high-fat diet, 3) CNTL: HFD + 500 mg CNT/kg BW, and 4) CNTH: HFD + 1500 mg CNT/kg BW. After a 25-week experimental period, CNT supplementation reduced (p <0.05) serum triacylglycerol (TAG), cholesterol crq and LDLC/HDLC ratio, and liver TAG contents. CNT supplementation downregulated (p <0.05) gene expressions of lipogenesis, but upregulated (p <0.05) gene expressions of cholesterol clearance/catabolism and energy expenditure. Serum trolox equivalent antioxidants capacity (TEAC), and liver glutathione (GSH) contents and glutathione-peroxidase (GPx) activity of HFD fed mice were also increased (p <0.05) by CNT supplementation. Besides, proinflammation related gene expressions (T1r4 and Nfkb) and proinflammatory cytokine (TNF-alpha) contents in livers of HFD fed mice were also decreased (p <0.05) by CNT supplementation. Furthermore, in comparison with the ameliorative effects of two-dosage CNT treatments on dyslipidemic and hepatic disorders induced by a high-fat diet, low dosage of CNT seems more effective than high dosage of CNT. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：497 / 508

页数：12

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