CD1a and langerin: acting as more than Langerhans cell markers

被引：62

作者：

Mizumoto, N ^{[1
]}

Takashima, A ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Dermatol, Dallas, TX 75230 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 05期

关键词：

D O I：

10.1172/JCI200421140

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Langerhans cells (LCs) represent a unique DC subset populating the outermost body surface, i.e., the epidermis. Although CD1a and langerin (CD207) are used as specific markers to distinguish LCs from other DC subsets, their immunological functions have remained mostly unknown. A new paper (see the related article beginning on page 701) demonstrates that LCs utilize these markers to induce cellular immune responses to Mycobacterium leprae: CD1a mediates the presentation of nonpeptide antigens to T cells, while langerin facilitates uptake of microbial fragments and perhaps their delivery to a specialized subcellular compartment.

引用

页码：658 / 660

页数：3

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