Association of the TP53 codon 72 polymorphism and breast cancer risk: a meta-analysis

被引:14
作者
Goncalves, Meire Luzia [1 ]
Borja, Sarah Moreira [1 ]
Bernardes Leao Cordeiro, Jacqueline Andrela [2 ]
Saddi, Vera Aparecida [1 ,3 ,5 ]
Ayres, Flavio Monteiro [4 ]
Sam Tiago Vilanova-Costa, Cesar Augusto [5 ]
Teodoro Cordeiro Silva, Antonio Marcio [1 ,5 ]
机构
[1] Pontificia Univ Catolica Goias, Dept Med, Setor Univ, BR-74605010 Goiania, Go, Brazil
[2] Univ Fed Goias, Fac Enfermagem, BR-74605080 Goiania, Go, Brazil
[3] Hosp Araujo Jorge, Associacao Combate Ao Canc Goias, Lab Oncogenet & Radiobiol, BR-74605070 Goiania, Go, Brazil
[4] Univ Estadual Goias, Unidade Univ Ciencias Exatas & Tecnol, BR-75132400 Anapolis, Go, Brazil
[5] Pontificia Univ Catolica Goias, Programa Posgrad Stricto Sensu Ciencias Ambientia, BR-74065140 Goiania, Go, Brazil
关键词
Arg72Pro; Genetic susceptibility; p53; R72P; Single nucleotide polymorphism; Breast cancer; BRCA2 MUTATION CARRIERS; P53; CODON-72; GENE POLYMORPHISMS; MDM2; SNP309; HAPLOTYPE ANALYSIS; TUNISIAN PATIENTS; INDIAN WOMEN; ARG72PRO; SUSCEPTIBILITY; VARIANTS;
D O I
10.1186/2193-1801-3-749
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This study was conducted in order to investigate the implications of the R72P polymorphism in the TP53 gene in breast cancer risk. The enlightenment of this matter might provide a piece of information about the potential implications of this polymorphism in patient risk. A meta-analysis was conducted considering a large sample size from studies with conflicting results on the R72P polymorphism in breast cancer patients. Relevant studies were selected from PubMed and SciELO databases for data extraction and statistical analysis. Database was built according to the continent and considering the genotype frequencies, sample size and genotyping methodology. The dominant models (RR vs RP + PP and RR + RP vs. PP), homozygous (RR vs. PP), heterozygous (RR vs. RP and RP vs. PP) and the allele (R vs. P) were used. Genotype frequencies were summarized and evaluated by chi(2) test of heterogeneity in 2x2 contingency tables with 95% CIs. Odds Ratios (OR) were calculated with a fixed-effect model (Mantel-Haenszel) or a random-effect model (DerSimonian-Laird) if the studies were considered homogeneous (P > 0.05) or heterogeneous (P < 0.05), respectively, using BioEstat (R) 5.0 software. Supported by a large sample size composed by 25,629 cases and 26,633 controls from 41 studies, we found significant association between the R72P polymorphism in the TP53 gene and the breast cancer risk. The overall data shows an increased risk due to the P allele dominant model, but not in Asia where the risk was associated with the R allele and R dominant model.
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页数:8
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