Eco-friendly polyethylene glycol (PEG-400): a green reaction medium for one-pot, four-component synthesis of novel asymmetrical bis-spirooxindole derivatives at room temperature

被引：42

作者：

Hasaninejad, Alireza ^{[1
]}

Beyrati, Maryam ^{[1
]}

机构：

[1] Persian Gulf Univ, Dept Chem, Fac Sci, Bushehr 7516913817, Iran

来源：

RSC ADVANCES | 2018年 / 8卷 / 04期

关键词：

CATALYST-FREE SYNTHESIS; DEEP EUTECTIC SOLVENTS; STRUCTURE-BASED DESIGN; HIGHLY EFFICIENT; SPIROINDOLOQUINAZOLINE DERIVATIVES; PYRAN DERIVATIVES; INHIBITORS;

D O I：

10.1039/c7ra13133j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

PEG-400 has been used as a green and biodegradable polymeric solvent for the one-pot, two-step, multicomponent synthesis of novel asymmetrical bis-spirooxindole derivatives by the reaction of N-alkyl isatin, isatin derivatives, alkylmalonates and C-H activated carbonyl compounds in the presence of K2CO3 at room temperature. Using this procedure, all the products were obtained in good to excellent yields.

引用

页码：1934 / 1939

页数：6

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