Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China

被引：178

作者：

Han, Huan ^{[1
]}

Xie, Linlin ^{[2
]}

Liu, Rui ^{[1
]}

Yang, Jie ^{[1
]}

Liu, Fang ^{[3
,4
]}

Wu, Kailang ^{[3
]}

Chen, Lang ^{[2
]}

Hou, Wei ^{[2
]}

Feng, Yong ^{[2
]}

Zhu, Chengliang ^{[1
]}

机构：

[1] Wuhan Univ, Dept Clin Lab, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China

[2] Sch Basic Med Sci, State Key Lab Virol, Dept Med Microbiol, Wuhan, Hubei, Peoples R China

[3] Coll Life Sci, State Key Lab Virol, Dept Virol, Wuhan, Hubei, Peoples R China

[4] Wuhan Inst Biotechnol, Wuhan, Hubei, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2020年 / 92卷 / 07期

基金：

中国国家自然科学基金;

关键词：

COVID-19; disease severity; heart injury; laboratory indicators; CORONAVIRUS; PNEUMONIA; OUTBREAK; SARS;

D O I：

10.1002/jmv.25809

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An outbreak of severe acute respiratory syndrome novel coronavirus (SARS-CoV-2) epidemic spreads rapidly worldwide. SARS-CoV-2 infection caused mildly to seriously and fatally respiratory, enteric, cardiovascular, and neurological diseases. In this study, we detected and analyzed the main laboratory indicators related to heart injury, creatine kinase isoenzyme-MB (CK-MB), myohemoglobin (MYO), cardiac troponin I (ultra-TnI), and N-terminal pro-brain natriuretic peptide (NT-proBNP), in 273 patients with COVID-19 and investigated the correlation between heart injury and severity of the disease. It was found that higher concentration in venous blood of CK-MB, MYO, ultra-TnI, and NT-proBNP were associated with the severity and case fatality rate of COVID-19. Careful monitoring of the myocardiac enzyme profiles is of great importance in reducing the complications and mortality in patients with COVID-19.

引用

页码：819 / 823

页数：5

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