Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide

被引：82
|
作者：
Ida, Tomoaki [1 ]
Hara, Masayuki [1 ]
Nakamura, Yoichi [2 ]
Kozaki, Shunji [2 ]
Tsunoda, Shigeru [3 ]
Ihara, Hideshi [1 ]
机构：
[1] Osaka Prefecture Univ, Grad Sch Sci, Dept Biol Sci, Naka Ku, Osaka 5998531, Japan
[2] Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Dept Vet Sci, Naka Ku, Osaka 5998531, Japan
[3] Osaka Prefecture Univ, Grad Sch Humanities & Social Sci, Dept Human Sci, Naka Ku, Osaka 5998531, Japan
来源：
NEUROSCIENCE LETTERS | 2008年 / 432卷 / 03期
关键词：
astrocytes; glutamate release; nitric oxide; cytokines;
D O I：
10.1016/j.neulet.2007.12.047
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cytokines are produced in the central nervous system (CNS) and exhibit various effects on neurons, microglia, and astrocytes. Astrocytes can release chemical transmitters, including glutamate, in a calcium-dependent manner, which may mediate communication between neurons and astrocytes. To date, no studies have been conducted on the effects of cytokines on calcium-dependent glutamate release from astrocytes. Here, we studied the effects of cytokines on calcium-dependent glutamate release. Cytokines enhanced glutamate release and induced the expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO). The inhibition of iNOS eliminated the cytokine-induced enhancement of glutamate release, and treatment with a NO donor, even in the absence of cytokines, increased glutamate release. Thus, cytokines enhance glutamate release, and this enhancement is mediated by NO. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：232 / 236
页数：5
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