Radiation therapy for T1,2 glottic carcinoma: Impact of overall treatment time on local control

被引:70
作者
Nishimura, Y
Nagata, Y
Okajima, K
Mitsumori, M
Hiraoka, M
Masunaga, S
Ono, K
Shoji, K
Kojima, H
机构
[1] KYOTO UNIV,INST RES REACTOR,OSAKA 59004,JAPAN
[2] KYOTO UNIV,FAC MED,DEPT OTOLARYNGOL,KYOTO 60601,JAPAN
关键词
laryngeal cancer; T1,2 glottic carcinoma; radiation therapy; overall treatment time; fractionation; SQUAMOUS-CELL CARCINOMA; RADICAL RADIOTHERAPY; DOSE-FRACTIONATION; LARYNGEAL-CANCER; MULTIVARIATE-ANALYSIS; PROGNOSTIC FACTORS; UTERINE CERVIX; VOLUME FACTORS; TUMOR; REPOPULATION;
D O I
10.1016/0167-8140(96)01796-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Local control probabilities of T1,2 glottic laryngeal cancer were evaluated in relation to dose and fractionation of radiation therapy (RT). Materials and methods: Between 1975 and 1993, 96 T1N0M0 glottic cancers and 32 T2N0M0 glottic cancers were treated with definitive RT. Total RT dose was 60-66 Gy/2 Gy for most of the T1 and T2 tumors, although 10 T2 tumors were treated with hyperfractionation (72-74.4 Gy/1.2 Gy bid). Of the 128 patients, 90 T1 glottic tumors and 30 T2 glottic tumors were followed for >2 years after treatment. Multivariate analyses using the Cox proportional hazards model and a logistic regression analysis were performed to evaluate the significance of prognostic variables on local control. Results: The 5-year local control probability for T1 tumors was 85%, whereas that for T2 tumors was 71%. Multivariate analyses demonstrated that only overall treatment time (OTT) was a significant variable for local control. Total RT dose, normalized total doses at a fraction size of 2 Gy, and fraction size were not significant. Local control probability of T1 tumors with an OTT of 42-49 days was significantly higher than that of tumors with an OTT of >49 days (P < 0.02). Only a 1-week interruption of RT, due to holidays, significantly reduced the 5-year local control probability of T1 glottic tumors from 89 to 74% (P < 0.05). Conclusions: These results indicate that OTT is a significant prognostic factor for local control of T1 glottic tumors.
引用
收藏
页码:225 / 232
页数:8
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