β1 integrins and neural stem cells:: making sense of the extracellular environment

被引：87
作者：
Campos, LS [1 ]
机构：
[1] Wellcome Trust Sanger Inst, Cambridge, England
来源：
BIOESSAYS | 2005年 / 27卷 / 07期
关键词：
D O I：
10.1002/bies.20256
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neural Stem Cells (NSC) are present in the developing and adult CNS. In both the embryonic and adult neurogenic regions, beta 1 integrins may act as sensors for the changing extracellular matrix. Here we highlight the integrative functions that beta 1 integrins may play in the "niche" by regulating NSC growth factor responsiveness in a timely and spatially controlled manner. beta 1 integrins may provide NSC with the capacity to react to a dynamic "niche", and to respond adequately by either remaining as stem cells or by differentiating and migrating away to shape the developing cortex. (c) 2005 Wiley Periodicals, Inc.
引用
收藏
页码：698 / 707
页数：10
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