Do Fetal Microchimeric Cells Influence Experimental Autoimmune Myocarditis?

被引：2

作者：

de Almeida Ribeiro, Roberto Stefan ^{[1
,4
]}

Demarque, Kelly Cristina ^{[2
]}

Figueiredo Junior, Israel ^{[3
]}

do Espirito Santo Rangel Ferreira, Isabeliza Maria ^{[1
]}

Valeriano, Jessica do Prado ^{[1
,4
]}

Vericimo, Mauricio Afonso ^{[1
,4
]}

机构：

[1] Fed Fluminense Univ, Inst Biol, Dept Immunobiol, Niteroi, RJ, Brazil

[2] Oswaldo Cruz Inst FIOCRUZ, Cell Biol Lab, Rio De Janeiro, Brazil

[3] Fed Fluminense Univ, Antonio Pedro Univ Hosp, Maternal & Child Dept, Niteroi, RJ, Brazil

[4] Fed Fluminense Univ, Grad Program Pathol, Niteroi, RJ, Brazil

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2022年 / 41卷 / 05期

关键词：

Pregnancy; microchimerism; fetal cells; semi-allogeneic cells; myocarditis; REGULATORY T-CELLS; MATERNAL TISSUE; MICE; PREGNANCY; MOUSE; AUTOANTIBODIES; PROGESTERONE; PROGRESSION; INDUCTION; DEPENDS;

D O I：

10.1080/15513815.2021.1994067

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective We investigated the presence and influence of fetal microchimerism in the cardiac tissue of mated female mice submitted to experimental autoimmune myocarditis. Materials and methods: Nulliparous BALB/c females and BALB/c females mated with either BALB/c males (syngeneic mating) or C57BL/6 males (allogeneic mating) were immunized with cardiac myosin peptide MyHC-alpha(614-629) or kept as non-immunized controls. Immunization occurred 6-8 weeks after delivery and mice were assessed after 21 days. Results: Immunized mice of allogeneic mating had a lower production of anti-MyHC-alpha(614-629) antibodies compared to immunized nulliparous mice. Immunized nulliparous females had an intense mononuclear inflammatory infiltrate in cardiac tissue, associated with fibroplasia, while mated females had a lower inflammatory reaction. An increase in the frequency of microchimeric fetal cells was observed in mice submitted to allogeneic mating following immunization. Conclusion: Allogeneic cells of fetal origin could contribute to mitigating the inflammatory response in experimental myocarditis.

引用

页码：781 / 793

页数：13

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