Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase

被引：7

作者：

Bakhanashvili, M ^{[1
]}

Novitsky, E

Rubinstein, E

Levy, I

Rahav, G

机构：

[1] Chaim Sheba Med Ctr, Infect Dis Unit, IL-52621 Tel Hashomer, Israel

[2] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 04期

关键词：

D O I：

10.1128/AAC.49.4.1576-1579.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the ability of p53 in cytoplasm to excise nucleoside analogs (NAs). A decrease in incorporation of NAs by human immunodeficiency virus type 1 reverse transcriptase and their excision from DNA by p53, provided by the cytoplasmic fraction of LCC2 cells, suggest that p53 in cytoplasm may act as an external proofreader for NA incorporation.

引用

页码：1576 / 1579

页数：4

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