Ecology and Evolution of Betacoronaviruses

被引:2
作者
Rodriguez-Roman, Eduardo [1 ]
Gibbs, Adrian J. [2 ]
机构
[1] Inst Venezolano Invest Cient, Ctr Microbiol & Cell Biol, Caracas, Venezuela
[2] Australian Natl Univ, Emeritus Fac, Canberra, ACT, Australia
来源
CORONAVIRUS DISEASE - COVID-19 | 2021年 / 1318卷
关键词
Betacoronaviruses; Coronaviruses; Ecology; Emergence; Evolution; Phylogeny; SARS-CoV-2; RESPIRATORY SYNDROME CORONAVIRUS; RNA VIRUSES; MOLECULAR EVOLUTION; INSECTIVOROUS BATS; SARS CORONAVIRUS; ANTS HYMENOPTERA; VIRAL MUTATION; RECOMBINATION; TRANSMISSION; RATES;
D O I
10.1007/978-3-030-63761-3_3
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The crown-like outline of the virions of coronaviruses will long endure as the iconic image of 2020 - the year of the COVID-19 pandemic. This major human health emergency has been caused by a betacoronavirus, as have others in the past. In this chapter, we outline the taxonomy of betacoronaviruses and their properties, both genetic and biological. We discuss their recombinational and mutational histories separately to show that the sequence of the RaTG13 bat virus isolate is the closest currently known full-length genetic homolog of that of the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). However, the RaTG13 bat virus and SARS-CoV-2 have probably diverged over 20 years. We discuss the ecology of their pangolin and bat hosts and conclude that, like other recent viral pandemics, the underlying cause of the SARS-CoV-2 emergence is probably the relentless growth of the world's human population and the overexploitation and disturbance of the environment.
引用
收藏
页码:41 / 60
页数:20
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