Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging

被引:59
作者
Yu, Siqing
Frueh, Beatrice E.
Steinmair, Dagmar
Ebneter, Andreas
Wolf, Sebastian
Zinkernagel, Martin S.
Munk, Marion R. [1 ]
机构
[1] Univ Bern, Inselspital, Bern Univ Hosp, Dept Ophthalmol, Bern, Switzerland
来源
PLOS ONE | 2018年 / 13卷 / 10期
关键词
FOVEAL AVASCULAR ZONE; DIABETIC-RETINOPATHY; CAPILLARY PLEXUSES; OXYGEN-SATURATION; VASCULAR DENSITY; RETINAL-VESSELS; SPECTRAL-DOMAIN; ARTIFACTS; EYES; MICROANGIOGRAPHY;
D O I
10.1371/journal.pone.0204501
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Purpose To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). Methods Prospective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photometry were performed post-surgery. Perfusion and vessel density of superficial (SCP) and deep capillary plexuses (DCP) of the 3 x 3 mm images as well as foveal avascular zone (FAZ) measurements were assessed. Vessel continuity, vessel visibility and presence of artefacts were evaluated by two blinded graders using a predefined grading protocol. Results Thirteen eyes of 12 patients met the inclusion criteria. There was a significant increase of perfusion and vessel densities in both the SCP and the DCP after cataract surgery within the 3 x 3 mm images. Significantly better distinguishability of FAZ border was observed postoperatively in both SCP and DCP, however, FAZ area and perimeter measurements did not significantly change after cataract surgery. Mean number of motion artifacts in SCP and DCP numerically decreased by 37% (P = .089) and 42% (P = .080). Conclusions Lens opacities have a significant influence on retinal blood flow measurements in SS-OCTA and should be considered in quantitative vessel analysis. Inflammation may also impact the assessment of density parameters. FAZ measurements seems to be the most robust parameters in terms of media opacity.
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页数:13
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