MANUFACTURING OF SUBSTITUTES FOR SPONGY BONE WITH INCREASED ABSORBABILITY

被引：1

作者：

Budnicka, Monika ^{[1
]}

Gadomska-Gajadhur, Agnieszka ^{[1
]}

Ruskowski, Pawel ^{[1
]}

机构：

[1] Warsaw Univ Technol, Fac Chem, Noakowskiego 3, PL-00664 Warsaw, Poland

来源：

CHEMICAL AND PROCESS ENGINEERING-NEW FRONTIERS | 2019年 / 40卷 / 04期

关键词：

porous implant; polylactide; Eudragit (R); freeze-extraction method; CASE SERIES; SCAFFOLDS; REGENERATION; DEFECTS; FABRICATION; IV;

D O I：

10.24425/cpe.2019.130215

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Composite scaffolds with increased hydrophilicity were prepared for cancellous bone regeneration by the freeze-extraction method. As a construction material, a poly-L-lactide (PLLA) was applied. As a hydrophilic, modifying agent a methacrylic acid copolymer, trade name Eudragit (R), was used. A preliminary investigation and optimization of the process were performed. For the obtained scaffolds, regression equations determining the effect of: Eudragit (R) E100/PLLA weight ratio; volume ratio of methanol (porophore)/PLLA solution in dioxane on interconnected porosity and mass absorbability of obtained implants were calculated.

引用

页码：411 / 423

页数：13

共 33 条

[1]

[Anonymous], 2018, SPOSOB WYTWARZANIA D

[2]

[Anonymous], FARM POL

[3]

[Anonymous], THESIS

[4]

[Anonymous], 2013, Int. Res. J. Pharm., DOI DOI 10.7897/2230-8407.04515

[5] Silk scaffolds with tunable mechanical capability for cell differentiation [J].

Bai, Shumeng ;

Han, Hongyan ;

Huang, Xiaowei ;

Xu, Weian ;

Kaplan, David L. ;

Zhu, Hesun ;

Lu, Qiang .

ACTA BIOMATERIALIA, 2015, 20 :22-31

[6] Long-term results and survival rate of implants treated with guided bone regeneration: a 5-year case series prospective study [J].

Blanco, J ;

Alonso, A ;

Sanz, M .

CLINICAL ORAL IMPLANTS RESEARCH, 2005, 16 (03) :294-301

[7] Effects of Polylactide Copolymer Implants and Platelet-Rich Plasma on Bone Regeneration within a Large Calvarial Defect in Sheep [J].

Blaszczyk, Bartlomiej ;

Kaspera, Wojciech ;

Ficek, Krzysztof ;

Kajor, Maciej ;

Binkowski, Marcin ;

Stodolak-Zych, Ewa ;

Grajoszek, Aniela ;

Stojko, Jerzy ;

Bursig, Henryk ;

Ladzinski, Piotr .

BIOMED RESEARCH INTERNATIONAL, 2018, 2018

[8] Bone tissue engineering using 3D printing [J].

Bose, Susmita ;

Vahabzadeh, Sahar ;

Bandyopadhyay, Amit .

MATERIALS TODAY, 2013, 16 (12) :496-504

[9] Recent advances in bone tissue engineering scaffolds [J].

Bose, Susmita ;

Roy, Mangal ;

Bandyopadhyay, Amit .

TRENDS IN BIOTECHNOLOGY, 2012, 30 (10) :546-554

[10] Preparation of polylactide scaffolds for cancellous bone regeneration - preliminary investigation and optimization of the process [J].

Budnicka, Monika ;

Trzaskowska, Joanna ;

Gadomska-Gajadhur, Agnieszka ;

Ruskowski, Pawel ;

Synoradzki, Ludwik .

PURE AND APPLIED CHEMISTRY, 2019, 91 (09) :1509-1519

← 1 2 3 4 →