Oscillatory haematopoiesis in adults with sickle cell disease treated with hydroxycarbamide

被引：7

作者：

Baird, John H. ^{[1
]}

Minniti, Caterina P. ^{[1
]}

Lee, Jung-Min ^{[2
]}

Tian, Xin ^{[3
]}

Wu, Colin ^{[3
]}

Jackson, Mary ^{[1
]}

Alam, Shoaib ^{[4
]}

Taylor, James G. ^{[1
]}

Kato, Gregory J. ^{[5
,6
]}

机构：

[1] NHLBI, Hematol Branch, Bethesda, MD USA

[2] NCI, Med Oncol Branch, NIH, Bethesda, MD 20892 USA

[3] NHLBI, Off Biostat Res, Bethesda, MD 20892 USA

[4] NHLBI, Cardiovasc & Pulm Branch, Bethesda, MD 20892 USA

[5] Univ Pittsburgh, Dept Med, Div Hematol Oncol, Pittsburgh, PA 15261 USA

[6] Univ Pittsburgh, Heart Lung Blood & Vasc Med Inst, Pittsburgh, PA 15261 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2015年 / 168卷 / 05期

基金：

美国国家卫生研究院;

关键词：

sickle cell disease; oscillatory haematopoiesis; hydroxycarbamide; complete peripheral blood count; periodicity; CHRONIC MYELOGENOUS LEUKEMIA; PLATELET COUNT OSCILLATIONS; TIME-SERIES ANALYSIS; CYCLIC LEUKOCYTOSIS; POLYCYTHEMIA-VERA; SPECTRAL-ANALYSIS; HYDROXYUREA; THROMBOPOIETIN; INDIVIDUALS; PERIODICITY;

D O I：

10.1111/bjh.13203

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hydroxycarbamide therapy has been associated with significant oscillations in peripheral blood counts from myeloid, lymphoid and erythroid lineages in patients with polycythaemia vera and chronic myeloid leukaemia. We retrospectively evaluated serial blood counts over an 8-year period from 44 adult patients with sickle cell disease receiving hydroxycarbamide. Platelet counts, leucocyte counts, haemoglobin values and reticulocyte counts, apportioned by hydroxycarbamide status, were analysed using a Lomb-Scargle periodogram algorithm. Significant periodicities were present in one or more counts in 38 patients receiving hydroxycarbamide for a mean duration of 481years. Platelet and leucocyte counts oscillated in 568% and 523% of patients, respectively. These oscillations generally became detectable within days of initiating therapy. During hydroxycarbamide therapy, the predominant periods of oscillation were 27 +/- 1d for platelet counts and 15 +/- 1d for leucocyte counts. Despite an absolute decrease in leucocyte and platelet counts during hydroxycarbamide treatment, the amplitudes between nadirs and zeniths remained similar regardless of exposure. Our observations appear consistent with previously proposed models of cyclic haematopoiesis, and document that hydroxycarbamide-induced oscillations in blood counts are innocuous phenomena not limited to myeloproliferative disorders as described previously. We speculate the known cell cycle inhibitory properties of hydroxycarbamide may accentuate otherwise latent constitutive oscillatory haematopoiesis.

引用

页码：737 / 746

页数：10

共 39 条

[11] Detecting periodic patterns in unevenly spaced gene expression time series using Lomb-Scargle periodograms [J].