Acquired EGFR T790M Mutation After Relapse Following EGFR-TKI Therapy: A Population-based Multi-institutional Study

被引：24

作者：

Kaburagi, Takayuki ^{[1
]}

Kiyoshima, Moriyuki ^{[1
]}

Nawa, Takeshi ^{[2
,3
]}

Ichimura, Hideo ^{[2
,3
]}

Saito, Takefumi ^{[4
]}

Hayashihara, Kenji ^{[4
]}

Yamada, Hideyasu ^{[5
]}

Satoh, Hiroaki ^{[6
]}

Endo, Takeo ^{[7
,8
]}

Inage, Yoshihisa ^{[7
,8
]}

Saito, Kazuhito ^{[9
,10
]}

Inagaki, Masaharu ^{[9
,10
]}

Hizawa, Nobuyuki ^{[11
]}

Sato, Yukio ^{[11
]}

Ishikawa, Hiroichi ^{[12
,13
]}

Sakai, Mitsuaki ^{[12
,13
]}

Kamiyama, Koichi ^{[14
]}

Kikuchi, Norihiro ^{[15
]}

Nakamura, Hiroyuki ^{[16
,17
]}

Furukawa, Kinya ^{[16
,17
]}

Kodama, Takahide ^{[18
]}

Yamashita, Takaaki ^{[19
]}

Nomura, Akihiro ^{[20
,21
]}

Yoshida, Susumu ^{[20
,21
]}

机构：

[1] Ibaraki Cent Hosp, Resp Ctr, Kasama, Ibaraki, Japan

[2] Hitachi Gen Hosp, Div Resp Med, Hitachi, Ibaraki, Japan

[3] Hitachi Gen Hosp, Div Thorac Surg, Hitachi, Ibaraki, Japan

[4] Ibarakihigashi Hosp, Div Resp Med, Tokai, Ibaraki, Japan

[5] Hitachinaka Gen Hosp, Div Resp Med, Hitachinaka, Ibaraki, Japan

[6] Univ Tsukuba, Mito Kyodo Gen Hosp, Div Resp Med, Mito Med Ctr, Miya Machi 3-2-7, Mito, Ibaraki 3058575, Japan

[7] Mito Med Ctr, Div Resp Med, Mito, Ibaraki, Japan

[8] Mito Med Ctr, Div Thorac Surg, Mito, Ibaraki, Japan

[9] Tsuchiura Kyodo Gen Hosp, Div Resp Med, Tsuchiura, Ibaraki, Japan

[10] Tsuchiura Kyodo Gen Hosp, Div Thorac Surg, Tsuchiura, Ibaraki, Japan

[11] Univ Tsukuba, Fac Clin Med, Tsukuba, Ibaraki, Japan

[12] Tsukuba Med Ctr Hosp, Div Resp Med, Tsukuba, Ibaraki, Japan

[13] Tsukuba Med Ctr Hosp, Div Thorac Surg, Tsukuba, Ibaraki, Japan

[14] Tsukuba Mem Hosp, Div Thorac Surg, Tsukuba, Ibaraki, Japan

[15] Kasumigaura Med Ctr, Div Resp Med, Tsuchiura, Ibaraki, Japan

[16] Tokyo Med Univ, Ibaraki Med Ctr, Div Resp Med, Ami, Ibaraki, Japan

[17] Tokyo Med Univ, Ibaraki Med Ctr, Div Thorac Surg, Ami, Ibaraki, Japan

[18] Ryugasaki Saiseikai Hosp, Div Resp Med, Ryugasaki, Japan

[19] JA Toride Med Ctr, Div Resp Med, Toride, Japan

[20] Ibaraki Seinan Med Ctr Hosp, Div Resp Med, Sakai, Osaka, Japan

[21] Ibaraki Seinan Med Ctr Hosp, Div Thorac Surg, Sakai, Osaka, Japan

来源：

ANTICANCER RESEARCH | 2018年 / 38卷 / 05期

关键词：

Acquired EGFR T790M gene mutation; epidermal growth factor; receptor-tyrosine kinase inhibitor; EGFR-TKI; population-based study; CELL LUNG-CANCER; RESISTANCE; AFATINIB; PLASMA; ASSOCIATION; CTDNA;

D O I：

10.21873/anticanres.12577

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To describe the prevalence and determinants of acquired epidermal growth factor receptor (EGFR) T790M gene mutation in a clinical practice setting. Materials and Methods: We performed a retrospective chart review study between January 2013 and November 2017 across multiple institutes, covering a population of 3 million people. Results: We reviewed the charts of 233 patients non-small cell lung cancer with EGFR mutations. Of them, 99 (42.5%) patients had acquired T790M mutations in EGFR. Patients >= 75 years old and patients with an exon 19 deletion had higher rates of acquired T790M mutation than did younger patients and those with an exon 21 L858R mutation. In 75 patients treated with afatinib, 34 (45.3%) patients had acquired T790M mutation. The sensitivity of T790M mutation detection was lower in plasma specimens than in biopsy specimens. Conclusion: This population-based study confirms previous studies and highlights potential determinants of acquired T790M mutation to be considered in clinical practice.

引用

页码：3145 / 3150

页数：6

共 17 条

[1] Acquired Resistance to First-Line Afatinib and the Challenges of Prearranged Progression Biopsies [J].

Campo, Meghan ;

Gerber, David ;

Gainor, Justin F. ;

Heist, Rebecca S. ;

Temel, Jennifer S. ;

Shaw, Alice T. ;

Fidias, Panos ;

Muzikansky, Alona ;

Engelman, Jeffrey A. ;

Sequist, Lecia V. .

JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (11) :2022-2026

[2] Plasma ctDNA Analysis for Detection of the EGFR T790M Mutation in Patients with Advanced Non-Small Cell Lung Cancer [J].

Jenkins, Suzanne ;

Yang, James C-H. ;

Ramalingam, Suresh S. ;

Yu, Karen ;

Patel, Sabina ;

Weston, Susie ;

Hodge, Rachel ;

Cantarini, Mireille ;

Janne, Pasi A. ;

Mitsudomi, Tetsuya ;

Goss, Glenwood D. .

JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (07) :1061-1070

[3]

Kawamura T, 2017, CLIN LUNG CANCER, V1525, P30210

[4] A Higher Proportion of the EGFR T790M Mutation May Contribute to the Better Survival of Patients with Exon 19 Deletions Compared with Those with L858R [J].

Ke, E-E ;

Zhou, Qing ;

Zhang, Qiu-Yi ;

Su, Jian ;

Chen, Zhi-Hong ;

Zhang, Xu-Chao ;

Xu, Chong-Rui ;

Yang, Jin-Ji ;

Tu, Hai-Yan ;

Yan, Hong-Hong ;

Zhang, Yi-Chen ;

Niu, Fei-Yu ;

Wu, Yi-Long .

JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (09) :1368-1375

[5] Frequency of EGFR T790M mutation and multimutational profiles of rebiopsy samples from non-small cell lung cancer developing acquired resistance to EGFR tyrosine kinase inhibitors in Japanese patients [J].

Ko, Ryo ;

Kenmotsu, Hirotsugu ;

Serizawa, Masakuni ;

Koh, Yasuhiro ;

Wakuda, Kazushige ;

Ono, Akira ;

Taira, Tetsuhiko ;

Naito, Tateaki ;

Murakami, Haruyasu ;

Isaka, Mitsuhiro ;

Endo, Masahiro ;

Nakajima, Takashi ;

Ohde, Yasuhisa ;

Yamamoto, Nobuyuki ;

Takahashi, Kazuhisa ;

Takahashi, Toshiaki .

BMC CANCER, 2016, 16

[6] EGFR mutation and resistance of non-small-cell lung cancer to gefitinib [J].

Kobayashi, S ;

Boggon, TJ ;

Dayaram, T ;

Janne, PA ;

Kocher, O ;

Meyerson, M ;

Johnson, BE ;

Eck, MJ ;

Tenen, DG ;

Halmos, B .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (08) :786-792

[7] Incidence of T790M mutation in (sequential) rebiopsies in EGFR-mutated NSCLC-patients [J].

Kuiper, J. L. ;

Heideman, D. A. M. ;

Thunnissen, E. ;

Paul, M. A. ;

van Wijk, A. W. ;

Postmus, P. E. ;

Smit, E. F. .

LUNG CANCER, 2014, 85 (01) :19-24

[8] Association of EGFR Exon 19 Deletion and EGFR-TKI Treatment Duration with Frequency of T790M Mutation in EGFR-Mutant Lung Cancer Patients [J].

Matsuo, Norikazu ;

Azuma, Koichi ;

Sakai, Kazuko ;

Hattori, Satoshi ;

Kawahara, Akihiko ;

Ishii, Hidenobu ;

Tokito, Takaaki ;

Kinoshita, Takashi ;

Yamada, Kazuhiko ;

Nishio, Kazuto ;

Hoshino, Tomoaki .

SCIENTIFIC REPORTS, 2016, 6

[9] Re-biopsy status among non-small cell lung cancer patients in Japan: A retrospective study [J].

Nosaki, Kaname ;

Satouchi, Miyako ;

Kurata, Takayasu ;

Yoshida, Tatsuya ;

Okamoto, Isamu ;

Katakami, Nobuyuki ;

Imamura, Fumio ;

Tanaka, Kaoru ;

Yamane, Yuki ;

Yamamoto, Nobuyuki ;

Kato, Terufumi ;

Kiura, Katsuyuki ;

Saka, Hideo ;

Yoshioka, Hiroshige ;

Watanabe, Kana ;

Mizuno, Keiko ;

Seto, Takashi .

LUNG CANCER, 2016, 101 :1-8

[10] Association Between EGFR T790M Status and Progression Patterns During Initial EGFR-TKI Treatment in Patients Harboring EGFR Mutation [J].

Oya, Yuko ;

Yoshida, Tatsuya ;

Kuroda, Hiroaki ;

Shimizu, Junichi ;

Horio, Yoshitsugu ;

Sakao, Yukinori ;

Inaba, Yoshitaka ;

Hida, Toyoaki ;

Yatabe, Yasushi .

CLINICAL LUNG CANCER, 2017, 18 (06) :698-+

← 1 2 →