A dielectric method for measuring early and late reactions in irradiated human skin

被引:76
作者
Nuutinen, J
Lahtinen, T [1 ]
Turunen, M
Alanen, E
Tenhunen, M
Usenius, T
Kolle, R
机构
[1] Kuopio Univ Hosp, Dept Oncol, FIN-70210 Kuopio, Finland
[2] Univ Kuopio, Dept Appl Phys, Res Inst Radiotherapy Phys, FIN-70210 Kuopio, Finland
关键词
dielectric constant; skin; radiotherapy; erythema; subcutaneous fibrosis;
D O I
10.1016/S0167-8140(97)00234-X
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background and purpose: To measure the dielectric constant of irradiated human skin in order to test the feasibility of the dielectric measurements in the quantitation of acute and late radiation reactions. Materials and methods: The dielectric constant of irradiated breast skin was measured at an electromagnetic frequency of 300 MHz in 21 patients during postmastectomy radiotherapy. The measurements were performed with an open-ended coaxial line reflection method. The irradiation technique consisted of an anterior photon field to the lymph nodes and a matched electron field to the chest wall using conventional fractionation of five fractions/week to 50 Gy. Fourteen out of the 21 patients were remeasured 2 years later and the skin was palpated for subcutaneous fibrosis. Results: At 5 weeks the dielectric constant had decreased by 31 and 39% for the investigated skin sites of the photon and electron fields, respectively. There was a statistically significant inverse correlation between the mean dielectric constant and the clinical score of erythema. An unexpected finding was a decrease of the dielectric constant of the contralateral healthy skin during radiotherapy. Two years later a statistically significant positive correlation was found between the dielectric constant at the irradiated skin sites and the clinical score of subcutaneous fibrosis. Conclusions: Dielectric measurements non-invasively yield quantitative information concerning radiation-induced skin reactions. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:249 / 254
页数:6
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