Prognostic value of novel neutrophil-to-hemoglobin and lymphocyte score in patients with acute myocardial infarction

被引：4

作者：

Kim, Hyeon Jeong ^{[1
]}

Lee, Jang Hoon ^{[1
,2
]}

Jang, Se Yong ^{[1
,2
]}

Bae, Myung Hwan ^{[1
,2
]}

Yang, Dong Heon ^{[1
,2
]}

Park, Hun Sik ^{[1
,2
]}

Cho, Yongkeun ^{[1
,2
]}

Jeong, Myung H. ^{[3
]}

Park, Jong-Seon ^{[4
]}

Kim, Hyo-Soo ^{[5
]}

Hur, Seung-Ho ^{[6
]}

Seong, In-Whan ^{[7
]}

Cho, Myeong-Chan ^{[8
]}

Chae, Shung Chull ^{[1
,2
]}

机构：

[1] Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea

[2] Kyungpook Natl Univ, Sch Med, Daegu, South Korea

[3] Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju, South Korea

[4] Yeungnam Univ Hosp, Dept Internal Med, Daegu, South Korea

[5] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea

[6] Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea

[7] Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea

[8] Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea

来源：

EUROPEAN JOURNAL OF INFLAMMATION | 2021年 / 19卷

关键词：

acute myocardial infarction; immune; inflammation; prognosis; biomarker; ACUTE CORONARY SYNDROME; BLOOD-CELL COUNT; CLINICAL-OUTCOMES; ELDERLY-PATIENTS; ANEMIA; INTERVENTION; MORTALITY; SUBTYPES; RISK; INFLAMMATION;

D O I：

10.1177/20587392211039095

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We developed and assessed whether a novel neutrophil-to-hemoglobin and lymphocyte (NHL) score would improve the ability to predict clinical outcome compared with neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) in acute myocardial infarction (AMI). We examined 13,072 AMI patients from the Korean AMI Registry-National Institute of Health database. NHL score was calculated as follows: NHL score (U) = N/(Hb x L), where N, Hb, and L are baseline blood neutrophil, hemoglobin, and lymphocyte count. The primary outcome was the occurrence of major adverse cerebrocardiovascular events (MACCEs) at 2 years. The NLR, SII, and NHL score were independent predictors of 2-year MACCEs. The area under the curve of the NHL score (0.637) for predicting 2-year MACCEs was significantly higher compared with those of SII (0.589) and NLR (0.607). The NHL score significantly improved the reclassification and integrated discrimination compared with NLR (p < 0.0001) and SII (p < 0.0001). A high NHL score (>= 0.35 U) was an independent predictor of 2-year MACCEs (adjusted hazard ratio, 1.41; 95% confidence interval, 1.29-1.55; p < 0.001). The NHL score could be a novel model for predicting long-term MACCEs in patients with AMI.

引用

页数：10

共 36 条

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