Studies on Isocyanides and related compounds:: A facile synthesis of 1,6-dihydro-6-oxopyrazine-2-carboxylic acid derivatives via ugi four-component condensation

被引：1

作者：

Faggi, C

García-Valverde, M

Marcaccini, S

Pepino, R

Pozo, MC

机构：

[1] Univ Florence, Dipartimento Chim Organ Ugo Schiff, I-50019 Sesto Fiorentino, FI, Italy

[2] Univ Florence, Ctr Interdipartimentale Cristallog, CRIST, I-50019 Sesto Fiorentino, FI, Italy

[3] Univ Burgos, Fac Ciencias, Dept Quim, Burgos 09001, Spain

来源：

SYNTHESIS-STUTTGART | 2003年 / 10期

关键词：

Ugi reaction; cyclizations; heterocycles; isocyanides; pyrazine ring synthesis;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Ugi four-component condensation (U-4CC) between arylglyoxals 7, amines 6, benzoylformic acid (4) and isocyanides 5 afforded the expected products 8 which were cyclized in a 5+1 fashion with ammonium acetate to give 1,N-disubstituted 4-aryl-1,6-dihydro-6-oxo-5-phenylpyrazine-2-carboxamides 9 in good yields. Evidence for the assigned structures 9 was provided by C-13 NMR spectra and X-ray analysis of 9a.

引用

页码：1553 / 1558

页数：6

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[1] SIR97:: a new tool for crystal structure determination and refinement [J].