Synthesis, in vitro cytotoxic and antiviral activity of cis-[Pt(R(-) and S(+)-2-α,-hydroxybenzylbenzimidazole)2Cl2] complexes

被引：56

作者：

Gökçe, M

Utku, S

Gür, S

Özkul, A

Gümüs, F

机构：

[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Ankara, Turkey

[2] Afyon Kocatepe Univ, Fac Vet Med, Dept Microbiol, Afyon, Turkey

[3] Ankara Univ, Fac Vet Med, Dept Virol, Ankara, Turkey

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 40卷 / 02期

关键词：

2-alpha-hydroxybenzylbenzin dazole; Pt(II) complexes; cytotoxic activity; antiviral activity;

D O I：

10.1016/j.ejmech.2004.09.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A pair of enantiomeric platinum(II) complexes of cis-[Pt(R(-) and S(+)-HBB)(2)Cl-2] (HBB = 2-alpha-hydroxybenzylbenzimidazole) was synthesized and evaluated for its preliminary in vitro cytotoxic activity on the human MCF-7 breast cancer and HeLa cervix cancer cell lines and antiherpes virus activity against bovine herpesvirus type 1 (BHV-1). In general, it was found that Pt(II) complexes were less cytotoxic on both cell lines than cisplatin and were comparable to carboplatin. There was no significant difference in cytotoxicity between two enantiomers, and the antiviral test results showed that the Pt(II) complexes and their carrier ligands R(-) and S(+) HBB had no effects inhibiting replication of BHV-1. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：135 / 141

页数：7

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